... development Retinoic acid signalling Head trunk interface Myogenesis Mouse AFM-Téléthon http://dx.doi.org/10.13039/100013465 24396 Agence Nationale de la Recherche http://dx.doi.org/10.13039/501100001665 ANR-19-CE13-0008 ANR-22-CE13-0047 Fondation Leducq http...

... how gene expression oscillations encode temporal information during vertebrate embryonic development by discussing the gene expression oscillations occurring during somitogenesis, neurogenesis, myogenesis and pancreas development. These oscillations play important but varied physiological functions...

... checkpoint that defines myogenic commitment could improve hPSC differentiation to skeletal muscle. Analysis of several myogenic factors in human embryos and early hPSC differentiations found SIX1 + PAX3 + co-expression was most indictive of myogenesis. Using dCas9-KRAB hPSCs, we demonstrate that early...

... cell Myogenesis Muscle fiber Embryonic muscle Fetal muscle Limb muscle Patterning Mouse Association Française contre les Myopathies http://dx.doi.org/10.13039/100013465 20313 22234 19507 21357 Agence Nationale de la Recherche http://dx.doi.org/10.13039/501100001665...

... patterning Homeodomain Homeotic transformation Myogenesis Skeletal patterning Vertebral patterning Anterior-posterior (AP) patterning is an essential feature of the bilaterian body plan and its mechanisms have been extensively studied. Segmental epithelial sacs known as somites emerge from...

...: The genesis of myogenic stem cells and their homing process during development are poorly known processes. We identified SIX homeoproteins as important regulators of this homing. Pax7 Six1 Six4 Homing Stem cells Myogenesis Muscle development in mouse takes place from embryonic day (E) 8...

... and misregulation of genes involved in muscle differentiation. Deletion of Myh3 during embryonic myogenesis leads to the depletion of the myogenic progenitor cell pool and an increase in the myoblast pool, whereas fetal myogenesis-specific deletion of Myh3 causes the depletion of both myogenic progenitor...

...Shuo Yang; Allison Weske; Yingqiu Du; Juliana M. Valera; Kenneth L. Jones; Aaron N. Johnson ABSTRACT Nascent myotubes undergo a dramatic morphological transformation during myogenesis, in which the myotubes elongate over several cell diameters and are directed to the correct muscle attachment sites...

...Shuang Cui; Liang Li; Ruth T. Yu; Michael Downes; Ronald M. Evans; Julie-Ann Hulin; Helen P. Makarenkova; Robyn Meech ABSTRACT Canonical Wnts promote myoblast differentiation; however, the role of β-catenin in adult myogenesis has been contentious, and its mechanism(s) unclear. Using CRISPR...

... in numerous developmental processes and dysregulated in a wide set of developmental disorders and cancers ( Imperial et al., 2017 ; Schlessinger, 2000 ; Tidyman and Rauen, 2009 ). Myogenesis Signal integration Founder cell Muscle progenitor Fusion competent myoblast Summary...

... are regulators of actin cycling and cytoskeletal gene expression. Loss of MRTFs in the mouse skeletal muscle causes muscle hypoplasia due to defects in sarcomere formation. Myogenesis MRTF SRF Actin cycling Myopathy National Institutes of Health 10.13039/100000002 HL-077439 HD-087351 DK...

...Jessica Williams; Nathan G. Boin; Juliana M. Valera; Aaron N. Johnson For skeletal muscle to produce movement, individual myofibers must form stable contacts with tendon cells and then assemble sarcomeres. The myofiber precursor is the nascent myotube, and during myogenesis the myotube completes...

...Amar J. Majmundar; David S. M. Lee; Nicolas Skuli; Rickson C. Mesquita; Meeri N. Kim; Arjun G. Yodh; Michelle Nguyen-McCarty; Bo Li; M. Celeste Simon Deeper insight into the molecular pathways that orchestrate skeletal myogenesis should enhance our understanding of, and ability to treat, human...

... and intrinsic regulatory mechanisms. Satellite cell Muscle stem cell Myogenesis Quiescence Cell cycle regulation Asymmetric division Self-renewal Skeletal muscle Regeneration Aging Skeletal muscles are made up of numerous multinucleated myofibers that possess the contractile machinery...

.... (D) Transactivation assay on C2C12 cells with the expression plasmids and reporters indicated ( n ≥3). (E) Schematic representation of the regulation of cell cycle exit during myogenesis. In muscle progenitors, Notch downstream effectors Hes1 and Hey1 repress the activation of p57 to allow...

... signaling suppressed both head and trunk myogenesis. Our findings, corroborated by mathematical modeling, suggest that ERK shuttling between the nucleus and the cytoplasm provides a switch-like transition between proliferation and differentiation of muscle progenitors. In situ hybridization of MyoD...

... NFAT and MyoD regulates myogenin expression and myogenesis . J. Biol. Chem. 283 , 29004 – 29010 . Armand A.-S. , Laziz I. , Djeghloul D. , Lécolle S. , Bertrand A. T. , Biondi O. , De Windt L. J. , Chanoine C. ( 2011 ). Apoptosis-inducing factor...

... about the molecular mechanisms that control the early stages of muscle morphogenesis. To explore this facet of myogenesis, we performed a genetic screen for regulators of somatic muscle morphology in Drosophila , and identified the putative RNA-binding protein (RBP) Hoi Polloi (Hoip). Hoip is expressed...

... regulatory role in muscle differentiation via Myod control. Although the involvement of Igf2 in myogenesis has been extensively studied, its exact function has not been elucidated. It has been shown that Igf2 acts on Myod by binding to the Igf1 receptor and activating the PI3K/Akt pathway in cultured...

...Boaz Gildor; Eyal D. Schejter; Ben-Zion Shilo A major aspect of indirect flight muscle formation during adult Drosophila myogenesis involves transition of a semi-differentiated and proliferating pool of myoblasts to a mature myoblast population, capable of fusing with nascent myotubes...