...-mail: [email protected] ) * These authors have contributed equally to the study 19 07 1999 07 09 1999 © 1999 by Company of Biologists 1999 Avian embryo Dermomyotome Dorsomedial lip MyoD Myf-5 Myogenin Myogenesis Neural tube Somite PAX Pioneer myotomal...

... and morphogenetic properties arise in the dorsomedial quadrant during somite maturation. * Author for correspondence (e-mail: [email protected] ) 1 10 1997 © 1997 by Company of Biologists 1997 quail-chick chimera somite myogenesis determination myoD myf-5 myotome notochord...

..., respectively, of the developing somite. To investigate the hypothesis that Myf-5 and MyoD have different roles in the development of epaxial and hypaxial musculature, we further characterized myogenesis in Myf-5- and MyoD -deficient embryos by several approaches. We examined expression of a MyoD-lacZ transgene...

...Stefanie Grass; Hans-Henning Arnold; Thomas Braun ABSTRACT Mice carrying a targeted mutation in the gene for the myogenic factor Myf-5 fail to form major parts of the ribs, which leads to an unstable thorax and perinatal death. Here, we report that somites of Myf-5 -deficient mice lack...

...Shahragim Tajbakhsh; Margaret E. Buckingham ABSTRACT myf-5 is one of four transcription factors belonging to the MyoD family that play key roles in skeletal muscle determination and differentiation. We have shown earlier by gene targeting nlacZ into the murine myf-5 locus that myf-5 expression...

...Thomas Braun; Eva Bober; Michael A. Rudnicki; Rudolf Jaenisch; Hans-Henning Arnold ABSTRACT The expression pattern of myogenic regulatory factors and myotome-specific contractile proteins was studied during embryonic development of Myf-5 mutant mice by in situ hybridization and immunohistochemistry...

... myotome limb muscle segmentation myogenesis paired box-containing genes myoD myf-5 All of the skeletal muscles of the avian body (excluding those of the head) arise from progenitor cells derived from the somites, condensations of paraxial (or segmental) mesoderm that form on either side...

... of muscle phenotypes at later times, raises the issue of how MyoD family genes are themselves regulated during development. In this work, we have initiated studies to identify DNA sequences that govern Myf-5 and MRF4 ( herculin, myf-6 ) transcription. Myf-5 is the first of the MyoD family to be expressed...

...Marie-Odile Ott; Eva Bober; Gary Lyons; Hans Arnold; Margaret Buckingham ABSTRACT We have analysed by in situ hybridization the expression of myf-5 , the murine homologue of the human myogenic regulatory sequence myf5, during embryogenesis in the mouse, myf-5 sequences were first detected...