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Keywords: mutation
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Journal Articles
Journal: Development
Development (2016) 143 (13): 2344–2355.
Published: 1 July 2016
... genetic linkage mapping and whole-exome sequencing, we identified a loss-of-function mutation in the Golgb1 gene that co-segregated with cleft palate in a new mutant mouse line. Golgb1 is a ubiquitously expressed large coiled-coil protein, also known as giantin, that is localized at the Golgi membrane...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (22): 3687–3696.
Published: 15 November 2008
.... * Author for correspondence (e-mail: cbb9@case.edu ) 24 9 2008 © 2008. 2008 Canonical Wnt signaling Activation Mutation Ventral patterning Cell fate Gli2 Gli3 Shh In the developing mammalian ventral spinal cord, five different neuronal cell types, comprising...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2002) 129 (8): 1995–2002.
Published: 15 April 2002
... residues, rescued fusion ability of the injected CD9 KO eggs. However, when the injected mouse CD9 mRNA contained a point mutation (F174 to A) the gamete fusion level was reduced fourfold, and a change of three residues (173-175, SFQ to AAA) abolished CD9’s activity in gamete fusion. These results suggest...
Journal Articles
Journal: Development
Development (2001) 128 (14): 2723–2733.
Published: 15 July 2001
... protein promoter. ‡Author for correspondence (e-mail: m0qiu001@louisville.edu ) 21 4 2001 © 2001. 2001 Oligodendrocytes Nkx2.2 Expression pattern Differentiation Mutation Rat Mouse At the early stage of neural development, the neural tube is made up of multipotent...
Journal Articles
Journal: Development
Development (2001) 128 (1): 95–105.
Published: 1 January 2001
... of retinal development, we have analyzed mutations in the mosaic eyes gene that disrupt retinal lamination, the localization of retinal cell divisions to the retinal pigmented epithelial surface and retinal pigmented epithelial development. Although retinal organization is severely disrupted in mosaic eyes...
Journal Articles
Journal: Development
Development (2000) 127 (3): 621–630.
Published: 1 February 2000
... 12 01 2000 © 2000 by Company of Biologists 2000 BMP BMPRIB Cartilage Mutation Mouse Specificity of BMP action is thought to be achieved in part by differential affinities of distinct ligands for one of four type I receptors: TSR-I (ALK1), ACTRI (ALK2), BMPRIA (ALK3...
Journal Articles
Journal: Development
Development (1998) 125 (18): 3719–3729.
Published: 15 September 1998
...Dennis S. Rice; Michael Sheldon; Gabriella D’Arcangelo; Kazunori Nakajima; Dan Goldowitz; Tom Curran ABSTRACT Mutation of either reelin ( Reln ) or disabled - 1 ( Dab1 ) results in widespread abnormalities in laminar structures throughout the brain and ataxia in reeler and scrambler mice. Both...
Journal Articles
Journal: Development
Development (1997) 124 (22): 4457–4466.
Published: 15 November 1997
..., Noggin and Follistatin. Specific defects in early dorsoventral patterning have been recently found in a number of zebrafish mutants, which exhibit either a ventralized or dorsalized phenotype. One of these, the ventralized mutant chordino (originally called dino ) is caused by a mutation in the zebrafish...
Journal Articles
Journal Articles
Journal: Development
Development (1993) 119 (1): 113–121.
Published: 1 September 1993
...J. Peter Estibeiro; Frances A. Brook; Andrew J. Copp ABSTRACT The mouse mutations splotch ( Sp ) and curly tail ( ct ) both produce spinal neural tube defects with closely similar morphology, but achieve this by different embryonic mechanisms. To determine whether the mutants may interact during...
Journal Articles
Journal: Development
Development (1992) 116 (Supplement): 65–73.
Published: 1 April 1992
... fate in the vertebrate embryo is determined by cell position. Work on the spadetail mutation will also be reviewed; this mutation causes a subset of mesodermal precursors to mismigrate during gastrulation thereby leading to a change in their eventual cell identity. © 1992 by Company of Biologists...
Journal Articles
Journal: Development
Development (1991) 113 (Supplement_2): 47–57.
Published: 1 April 1991
... zygotic lethal mutations to analyze the assembly of this ‘primary’ embryonic nervous system. Here we focus on spinal primary motoneurons, their inputs from hindbrain Mauthner neurons, and their outputs to segmental body wall muscle. The mutation nic-1 blocks synaptic transmission between nerve and muscle...
Journal Articles
Journal: Development
Development (1990) 108 (3): 443–459.
Published: 1 March 1990
...Adam L. Felsenfeld; Charline Walker; Monte Westerfield; Charles Kimmel; George Streisinger We describe embryonic lethal mutations in the zebrafish, Brachydanio rerio , which affect organization of skeletal muscle myofibrils. The mutations, fub-l(b45) and fub-l( b126) , were independently isolated...
Journal Articles
Journal: Development
Development (1986) 96 (1): 295–302.
Published: 1 July 1986
... either reversal of inactivation, or the frequency with which the influence of the X chromosome extends to the albino locus. 11 04 1986 Copyright © 1986 by Company of Biologists 1986 X-inactivation mosaics pigmentation genetic activity Cattanach’s insertion albino mouse mutation...
Journal Articles
Journal: Development
Development (1986) 92 (1): 85–101.
Published: 1 March 1986
...Earl H. Webster, Jr; Johan Zwaan; Philip Cooper ABSTRACT Sulphated materials were tested for in the eyes of late gestational and postnatal normal mice and mice with the aphakia mutation using Spicer’s high iron diamine staining method. Qualitative identification of these materials was attempted...
Journal Articles
Journal: Development
Development (1986) 91 (1): 65–78.
Published: 1 February 1986
... melanophore periodic albino Xenopus laevis mutation epidermis dermis pigmentation Periodic albinism ( a p ) of Xenopus laevis was first described by Hoperskaya (1975) . This mutant is characterized by (1) the complete absence of melanin in oocytes, (2) the appearance of melanin...