... unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Summary: Using mouse genetics and human neural organoids, we assessed the consequences of reducing the activity of a metabolic enzyme, DHFR, on the production of different neuronal...

.... Twist1 -interacting Irf6 is involved in regulating neural tube integrity. Mouse genetics Neural tube closure Epithelial-to-mesenchymal transition Neural tube explants Cell delamination Cell migration University of Texas Health Science Center at Houston http://dx.doi.org/10.13039...

... mutants. Cell polarity Cytoskeleton Inner ear Morphogenesis Mouse genetics Sensory hair cell Mouse MPDZ is required to maintain the lateral polarization of GNAI-GPSM2 at the apical membrane from P4 ( Fig. 2 ), and CRB3-MPP5-MPDZ is more highly enriched at the bare zone compared...

... tracing and targeted gene disruption and gain of function identify a novel source of lymphatic endothelial progenitors that contribute to the formation of lymphatic vasculature in mouse skin. Lymphatic endothelial cells Skin Lymphangiogenesis PROX1 Lineage tracing Progenitor cell Mouse...

... Highlighted article: In the neuroepithelium, apical cofilin 1 activates actomyosin contractility to promote neural tube closure, while basally it prevents ectopic myosin activation and tight junction formation. SHROOM3 Actin Cofilin Epithelial polarity Mouse genetics Neural tube Animal...

... levels. Within these columns, a stereotypic organization into discrete pools of motor neurons reflects their axonal trajectories, as well as their patterns of target innervation ( Hollyday, 1980 ; Gutman et al., 1993 ). Hox genes Collinearity Transcriptional regulation Mouse genetics...

[email protected] ; [email protected] ) Competing interests statement The authors declare no competing financial interests. 22 1 2010 © 2010. 2010 COPII-mediated protein trafficking Planar cell polarity Neural tube closure defect Mouse genetics Inner ear development Cardiac...

... for correspondence (e-mail: [email protected] ) * Present address: Oncodesign, Dijon 21076, France 20 8 2008 © 2008. 2008 Cell cycle regulation Cyclin Cyclin-dependent kinase (Cdk) Meiosis Mouse genetics Cyclin-dependent kinases (Cdks) together with cyclins constitute...

... necessary for repression of the paternal allele. 09 03 1994 © 1994 by Company of Biologists 1994 imprinting methylation androgenetic parthenogenetic embryonic stem cells embryoid bodies mouse genetics Endogenously imprinted genes are defined as those that exhibit inequality...

... 10032, USA † The Biological Laboratories, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA 30 03 1993 © 1993 by Company of Biologists 1993 parental imprinting insulin-like growth factor 2 T-maternal effect mouse genetics It is well established...

... to a genetically mapped locus called extra-toes (Xt) . The phenotype of the double-mutant addjXt as well as the molecular analysis suggest that add and Xt are allelic. 20 08 1990 © 1990 by Company of Biologists 1990 morphogenetic mutations mouse genetics pattern formation insertional...

.... genome imprinting transgenic mice mouse genetics ...

... expression mouse genetics cDNA cloning spermatogenesis. The mouse t -complex is a region of chromosome 17, found in wild mouse populations, which is grossly rearranged when compared to those of normal laboratory strains. So far, two large, independent inversions have been demonstrated. The distal...