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Keywords: mouse embryo
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Journal Articles
Journal: Development
Development dev.199655.
Published: 17 January 2022
... knowledge of the spatial organization of distinct cell types in the embryonic pancreatic tissue is still largely based on 2D histological sections. Here, we present a light-sheet fluorescence microscopy approach to image the pancreas in 3D and map tissue interactions at key time points in the mouse embryo...
Journal Articles
Journal: Development
Development (2021) 148 (1): dev193789.
Published: 07 January 2021
...Simone Probst; Sagar; Jelena Tosic; Carsten Schwan; Dominic Grün; Sebastian J. Arnold ABSTRACT Anterior mesoderm (AM) and definitive endoderm (DE) progenitors represent the earliest embryonic cell types that are specified during germ layer formation at the primitive streak (PS) of the mouse embryo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (21): dev187187.
Published: 12 November 2020
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (10): dev188714.
Published: 26 May 2020
... of the organelle. Although mutations in MRPs have been associated with human diseases, little is known about their role during development. Presented here are the null phenotypes for 21 nuclear-encoded mitochondrial proteins and in-depth characterization of mouse embryos mutant for the Mrp genes Mrpl3 , Mrpl22...
Journal Articles
Journal: Development
Development (2018) 145 (19): dev164319.
Published: 02 October 2018
... molecular markers to identify them. Here, we elucidate the expression pattern of the transcription factor Nkx1-2 in the mouse embryo and show that it identifies axial progenitors throughout body axis elongation, including neuromesodermal progenitors and early neural and mesodermal progenitors. We create...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (8): 1271–1283.
Published: 15 April 2016
.... BAF complex Chromatin remodelling Epigenetics Lineage specification Mouse embryo Pluripotency SMARCC1 Differentiation involves a cascade of cell fate decisions that progressively limit the potential of a cell to contribute to other lineages. Two cell fate decisions take place in the pre...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (5): 872–879.
Published: 01 March 2016
... compromises migration of myogenic cells to the limb. Mouse embryo Forelimb bud Myogenic cells Somite-derived endothelial cells Pax3 Foxc1 Foxc2 The failure of myogenic progenitors to migrate into the forelimb does not appear to reflect an obvious deficit in these cells and indeed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (21): 3649–3660.
Published: 01 November 2015
... approaches to constitutively activate the NOTCH pathway in the mouse embryo. Early embryonic development, including the establishment of anterior-posterior polarity, is not perturbed by forced NOTCH activation. By contrast, widespread NOTCH activity in the epiblast triggers dramatic gastrulation defects...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (11): 2349–2359.
Published: 01 June 2014
... organisms such as early post-implantation mouse embryos. We introduce here a microdevice to achieve localised electroporation with high efficiency and reduced cell damage. In silico simulations using a simple electrical model of mouse embryos indicated that a dielectric guide-based design would improve...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (5): 1140–1150.
Published: 01 March 2014
...-Cerezales S. , Bermejo-Alvarez P. , Ramirez M. A. , Gutierrez-Adan A. ( 2012 ). Long-term and transgenerational effects of in vitro culture on mouse embryos . Theriogenology 77 , 785 – 793 . Cantone I. , Fisher A. G. ( 2013 ). Epigenetic programming...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (7): 1583–1593.
Published: 01 April 2013
... D. ( 1995 ). What can be learned from intermediate filament gene regulation in the mouse embryo . Int. J. Dev. Biol. 39 , 443 – 457 . Ertürk A. , Hellal F. , Enes J. , Bradke F. ( 2007 ). Disorganized microtubules underlie the formation of retraction bulbs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (20): 3722–3731.
Published: 15 October 2012
... specification of embryonic blastomeres by sequentially separating the blastomeres in two-cell stage mouse embryos and continuing separation after each cell division throughout pre-implantation development. This procedure eliminates information provided by cell-cell interaction and cell positioning. Gene...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (17): 3248–3256.
Published: 01 September 2012
... of the generated mice will be embryonic lethal; therefore, phenotyping methods tuned to the mouse embryo are needed. Methods that are robust, quantitative, automated and high-throughput are attractive owing to the numbers of mice involved. Three-dimensional (3D) imaging is a useful method for characterizing...
Journal Articles
Journal: Development
Development (2012) 139 (16): 2866–2877.
Published: 15 August 2012
... financial interests. 28 5 2012 © 2012. Pluripotent stem cells Directed differentiation Extra-embryonic endoderm FGF Mouse embryo Early mammalian embryogenesis is characterized by a gradual restriction in the developmental potential of cells that constitute...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (13): 2288–2298.
Published: 01 July 2012
... locks. ‡ Authors for correspondence ( ichambers@ed.ac.uk ; v.wilson@ed.ac.uk ) * These authors contributed equally to this work Competing interests statement The authors declare no competing financial interests. 25 4 2012 © 2012. Pluripotency Mouse embryo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (8): 1522–1533.
Published: 15 April 2012
... statement The authors declare no competing financial interests. 17 2 2012 © 2012. Dermis Mouse embryo Fibroblasts Hair follicle Wnt β-catenin En1Cre ( Kimmel et al., 2000 ), HoxB6CreER T1 ( Nguyen et al., 2009 ), K14Cre ( Dassule et al., 2000 ), ROSA26R...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (2): 423–436.
Published: 15 January 2012
...Marieke Cajal; Kirstie A. Lawson; Bill Hill; Anne Moreau; Jianguo Rao; Allyson Ross; Jérôme Collignon; Anne Camus In the mouse embryo the anterior ectoderm undergoes extensive growth and morphogenesis to form the forebrain and cephalic non-neural ectoderm. We traced descendants of single ectoderm...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (8): 1521–1530.
Published: 15 April 2011
...Daniel W. Stuckey; Melanie Clements; Aida Di-Gregorio; Claire E. Senner; Paul Le Tissier; Shankar Srinivas; Tristan A. Rodriguez During development, the growth of the embryo must be coupled to its patterning to ensure correct and timely morphogenesis. In the mouse embryo, migration of the anterior...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (6): 1093–1097.
Published: 15 March 2011
... interests statement The authors declare no competing financial interests. 17 12 2010 © 2011. 2011 Mouse embryo Wilms' tumour suppressor gene Retinoic acid Raldh2 Epicardium Retinoic acid (RA) regulates a variety of crucial events during early embryonic development, acting...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (20): 3361–3372.
Published: 15 October 2010
...) as an early marker of the PrE lineage and its derivatives in both mouse embryos and ex vivo paradigms of extra-embryonic endoderm (ExEn). By combining live imaging of embryos and embryo-derived stem cells expressing a histone H2B-GFP fusion reporter under the control of Pdgfra regulatory elements...
Includes: Multimedia, Supplementary data