1-20 of 1844
Keywords: mouse
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles
Journal: Development
Development (2021) 148 (23): dev200182.
Published: 03 December 2021
... target genes have remained largely elusive. Here, we identify the SMAD4 target genes in mouse limb buds using an epitope-tagged Smad4 allele for ChIP-seq analysis in combination with transcription profiling. This analysis shows that SMAD4 predominantly mediates BMP signal transduction during early limb...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (23): dev199607.
Published: 02 December 2021
... Highlighted Article: A gain-of-function point mutation in mouse PDGFRβ causes osteopenia associated with intrinsic changes in skeletal stem cells that promote chondrogenesis over osteogenesis. Skeletal stem cells Platelet-derived growth factor receptor beta Penttinen syndrome Kosaki overgrowth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development dev.200059.
Published: 25 November 2021
... organizing center for axial elongation in mouse embryos. The T-box transcription factor Brachyury (T) is essential for both, formation of the notochord and maintenance of NMPs, and thus is a key regulator of trunk and tail development. The T promoter controlling T expression in NMPs and nascent mesoderm has...
Journal Articles
Journal: Development
Development (2021) 148 (21): dev199940.
Published: 10 November 2021
... poorly understood. Here, we identify a regulatory pathway that controls alveolar progenitor differentiation and lactation by governing Notch activation in mouse. Loss of Robo1 in the mammary gland epithelium activates Notch signaling, which expands the alveolar progenitor cell population at the expense...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (21): dev199683.
Published: 09 November 2021
... NF-κB, together with downstream Wnt and Sox9, is required for Paneth and goblet cell fate decisions and for maintenance of the small intestinal stem cell niche. NF-κB Intestine Paneth cells Goblet cells Stem cells Epithelial self-renewal Mouse Deutsche Forschungsgemeinschaft...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (21): dev199926.
Published: 05 November 2021
... and primitive endoderm-like cells in mouse embryonic stem cell cultures emerges at the population level through cell-cell communication via a short-range fibroblast growth factor 4 (FGF4) signal. We characterize the molecular and dynamical properties of the communication mechanism and show how it controls both...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (21): dev199644.
Published: 29 October 2021
... and reproduction in any medium provided that the original work is properly attributed. Summary: FAM71F1 interacts with RAB2A/B and regulates the formation of the acrosome in mice, the misregulation of which impacts male fertility. Acrosome Spermatogenesis Globozoospermia Mouse Ministry...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (21): dev199560.
Published: 29 October 2021
... is increased in Aurkb knockout mouse oocytes and demonstrate that this increase drives the excess translation. Importantly, removal of one copy of Aurka from the Aurkb knockout strain background reduces aneuploidy rates. This study demonstrates that AURKA is required for CPEB1-dependent translation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (8): dev199783.
Published: 26 October 2021
...); CD19 −/− dams gave birth at 0.4 but not 0.2 mg LPS/kg BW, whereas BMyD88 −/− mice delivered following i.p. injection of LPS at both 0.4 and 0.2 mg/kg BW ( Fig. 4 B-D). MyD88 −/− mice did not deliver at any tested LPS concentration ( Fig. 4 A-C). No mouse strain gave birth within 24 h after PBS...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (20): dev199581.
Published: 26 October 2021
... Scholarship (to Z.L.G.); and the Royal Melbourne Hospital Neuroscience Foundation (R.C.A.S.). The neonatal mouse retina is a widely used model of angiogenesis, in which both vessel sprouting in response to pro-angiogenic factors and subsequent vessel network remodelling occur in parallel ( Fig. 1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (20): dev199732.
Published: 19 October 2021
... the differentiation model of mouse epiblast stem cells (EpiSCs), we have shown that two defined EpiSC lines have robust germ cell differentiation competence. However, another defined EpiSC line has no competence. By evaluating the molecular basis of EpiSCs with distinct germ cell differentiation competence, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (19): dev199585.
Published: 05 October 2021
... 23 8 2021 © 2021. Published by The Company of Biologists Ltd 2021 Highlighted Article: The psychoactive cannabinoid THC inhibits Hedgehog signaling in genetically sensitized mouse embryos, consistent with a gene–environment interaction model for the etiology of a common birth...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (19): dev198374.
Published: 30 September 2021
... of proteins mediates movement of specific cargo proteins when bound to karyopherin β. Karyopherin α genes have distinct expression patterns in mouse testis, implying they may have unique roles during mammalian spermatogenesis. Here, we use a loss-of-function approach to determine specifically the role...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (19): dev199580.
Published: 24 September 2021
... Tbx4 Pitx1 Mouse Medical Research Council MC PC 13052 MR/S000038/1 Forelimbs and hindlimbs arise as outgrowths from the lateral plate mesoderm and form at fixed positions along the body axis. Forelimbs form at the cervical/thoracic junction whereas hindlimbs form...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (19): dev199738.
Published: 23 September 2021
... underlying how stromal AR maintains the cell niche in support of pubertal prostatic epithelial growth are unknown. Here, using advanced mouse genetic tools, we demonstrate that selective deletion of stromal AR expression in prepubescent Shh-responsive Gli1 -expressing cells significantly impedes pubertal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (17): dev199534.
Published: 07 September 2021
... and maxillary portions of the first arch. Here, we show that disruption of Gata3 in mouse embryos leads to craniofacial microsomia and syngnathia (bony fusion of the upper and lower jaws) that results from changes in BMP4 and FGF8 gene regulatory networks within NCCs near the maxillomandibular junction. GATA3...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (16): dev196642.
Published: 19 August 2021
.... The transcription factor zinc finger and BTB domain-containing protein 20 (ZBTB20) has been implicated in regulation of cell specification during neocortical development. Here, we show that ZBTB20 instructs the generation of a subset of callosal projections neurons in cortical layers II/III in mouse. Conditional...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (16): dev197020.
Published: 12 August 2021
... that Lrig1 acts through this mechanism to inhibit Ret activity. However, it is unclear whether other Lrig family members play similar roles. Here, we show that Lrig1 and Lrig3 are co-expressed in Ret-positive mouse dorsal root ganglion (DRG) neurons. Lrig3, like Lrig1, interacts with Ret and inhibits GDNF...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (16): dev199686.
Published: 12 August 2021
... of the mitochondrial network results in packing of mitochondria into a tight array in the sperm midpiece to fuel motility. Here, we show that disruption of mouse Fis1 in the male germline results in early spermatid arrest that is associated with increased mitochondrial content. Mutant spermatids coalesce...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (18): dev199778.
Published: 12 August 2021
.... Published by The Company of Biologists Ltd 2021 Summary: This review presents in vivo imaging methods currently used to investigate adult neural stem cell activation and physiology. Adult neural stem cells In vivo imaging Mini-endoscopes Mouse Two-photon imaging Zebrafish...