... absent ( eya ) mutant discs and, as a result, the initiation of retinal patterning is blocked. Based on these observations, Eya has been proposed to control the initiation of the morphogenetic furrow via regulation of Dpp signaling within the M. We show that the failure in pattern formation surprisingly...

... for initiation of the morphogenetic furrow in the eye itself. Loss of Ey within the peripodial epithelium leads to the loss of dpp expression within the eye, failure of the furrow to initiate, and abrogation of retinal development. These findings reveal an unexpected mechanism for how Pax6 controls eye...

...Carrie M. Spratford; Justin P. Kumar The compound eye of Drosophila melanogaster is configured by a differentiating wave, the morphogenetic furrow, that sweeps across the eye imaginal disc and transforms thousands of undifferentiated cells into a precisely ordered repetitive array of 800 ommatidia...

...: Howard Hughes Medical Institute, Janelia Farm Research Campus, Ashburn, VA 20147, USA 17 2 2006 © 2006. 2006 Drosophila moleskin Importin 7 Morphogenetic furrow MAP kinase Cell cycle Nuclear translocation ERK Hedgehog Dpp Egfr...

...Aloma B. Rodrigues; Erica Werner; Kevin Moses A key event in patterning the developing Drosophila compound eye is the progressive restriction of the transcription factor Atonal in the morphogenetic furrow. The Atonal pattern evolves from expression in all cells to an over-dispersed pattern...

... in the compound eye is fundamentally different: the boundary is not stable, but moves (the morphogenetic furrow). Paradoxically, Hedgehog signaling is essential to both:Hedgehog is expressed in the posterior compartments in the embryo and in imaginal discs, and posterior to the morphogenetic furrow in the eye...

... 2003. 2003 Drosophila eye Morphogenetic furrow Hedgehog Decapentaplegic Notch Delta The adult eye of Drosophila is remarkable for a wave of differentiation that spreads from posterior to anterior across the retina field of the eye imaginal disc. Eight hundred or so ommatidia...

... does it regulate ey expression, (2) eyg -induced ectopic morphogenetic furrow formation does not require ey , nor does ey -induced ectopic eye production require eyg , (3) eyg and ey can partially substitute for the function of the other, and (4) coexpression of eyg and ey has a synergistic enhancement...

... hedgehog Drosophila Retinal determination cubitus interruptus Photoreceptor Morphogenetic furrow Members of the Hedgehog family of secreted signaling proteins play crucial roles throughout development (recently reviewed by Ingham and McMahon, 2001 ). Much of our understanding...

... of the R8 `founder' photoreceptor in each cluster( Jarman et al., 1994 ). These cells then differentiate as photoreceptors and themselves express hh ,allowing the cycle to propagate toward the anterior of the disc. dpp is expressed in the morphogenetic furrow, an indentation at the front...

...Kenneth M. Cadigan; Austin D. Jou; Roel Nusse In the developing eye, wingless activity represses proneural gene expression (and thus interommatidial bristle formation) and positions the morphogenetic furrow by blocking its initiation in the dorsal and ventral regions of the presumptive eye. We...

...Justin P. Kumar; Kevin Moses The onset of pattern formation in the developing Drosophila retina begins with the initiation of the morphogenetic furrow, the leading edge of a wave of retinal development that transforms a uniform epithelium, the eye imaginal disc into a near crystalline array...

... signaling promotes the growth of cells in the eye disc, and is sufficient to maintain cells in a state in which they fail to differentiate and continue to express anterior markers. Such ectopic anterior cells can reorient the direction of morphogenetic furrow progression. Conversely, the posterior signals...

...Catherine A. Brennan; Tong-Ruei Li; Michael Bender; Frank Hsiung; Kevin Moses ABSTRACT The progression of the morphogenetic furrow in the developing Drosophila eye is an early metamorphic, ecdysteroid-dependent event. Although Ecdysone receptor -encoded nuclear receptor isoforms are the only known...

...Simon Greenwood; Gary Struhl During Drosophila eye development, Hedgehog (Hh) protein secreted by maturing photoreceptors directs a wave of differentiation that sweeps anteriorly across the retinal primordium. The crest of this wave is marked by the morphogenetic furrow, a visible indentation...

... specification initiate at a moving boundary known as the morphogenetic furrow. We have investigated the role of ecdysone in eye development and report here that the ecdysone signaling pathway is required for progression of the morphogenetic furrow in the eye imaginal disc of Drosophila . Genetic disruption both...

..., are required for progression of the morphogenetic furrow across the primordium. Proliferation, cell-type specification and organization of immature ommatidial clusters occur in conjunction with furrow progression. These events can be reversibly started or stopped in cultured primordia simply by adjusting...

...David I. Strutt; Marek Mlodzik ABSTRACT Pattern formation in the eye imaginal disc of Drosophila occurs in a wave that moves from posterior to anterior. The anterior edge of this wave is marked by a contracted band of cells known as the morphogenetic furrow, behind which photoreceptors...

... discs, the tissues that will give rise to the adult cuticle structures. This is well demonstrated in the control of morphogenetic furrow movement and differentiation in the eye imaginal disc. We report that ultraspiracle , the gene encoding the Drosophila cognate of the Retinoid X Receptor, is required...

... is initiated at the posterior edge and moves anteriorly as a wave; the front of this wave is called the morphogenetic furrow (MF). Dpp is required for proliferation and initiation of pattern formation at the posterior edge of the eye disc. It has also been suggested that Dpp is the principal mediator...