...., 2014 ). Similarly, while the Wnt pathway has been shown to influence actin dynamics ( Stamatakou et al., 2015 ), how this could lead to nucleation and alignment of myonemes along morphogen gradients remains unknown. Our suggested mechanochemical model for Hydra morphogenesis bears similarities...

.... Tubulogenesis Morphogenesis Cell polarity Mechanical forces Lumen National Institute of Diabetes and Digestive and Kidney Diseases http://dx.doi.org/10.13039/100000062 R01DK115655 Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston...

...-mediated auxin signalling machineries in Arabidopsis and Capsella reveals conserved functions in Brassicaceae with distinct fruit shapes. Gynoecium Fruit Auxin Polarity Morphogenesis Signalling John Innes Foundation http://dx.doi.org/10.13039/501100004034 Gatsby...

... removal of dorsal progenitors in the zebrafish tailbud using multiphoton ablation. This led to a proportional reduction in the length of the spinal cord and paraxial mesoderm in the tail, revealing a capacity for the regulation of tissue morphogenesis during tail formation. Following analysis of cell...

... molecular regulation of C&E differs between tissues remains an open question. Using a zebrafish explant model of AP axis extension, we show that C&E of the neuroectoderm and mesoderm can be uncoupled ex vivo , and that morphogenesis of individual tissues results from distinct morphogen signaling...

... constriction forces into lateral cell elongation and tissue folding. Here, we have investigated embryonic morphogenesis in anillin knockdown ( scra RNAi) embryos, where basal cell membranes fail to form and therefore cells can lose cytoplasmic volume through their basal side. Surprisingly, the mesoderm...

... averaging of cell growth, preserving robust organ morphogenesis, whereas correlated growth fluctuations impair averaging. Cell growth does not accumulate into averaged growth in ftsh4-5 ( Fig. 7D ). Instead, growth accumulated in patches that cover parts of the sepal instead of encompassing the entire...

... flux influence DTC elaboration. We propose a ‘hitch and tow’ aspect of organ-level dynamics that contributes to cellular morphogenesis, whereby germline flux drags the flexible DTC cell cortex away from its stationary cell body. More broadly, we speculate that this mechanism may contribute to cell...

..., leading to a short ventricle and outflow tract abnormalities. Heart development Second heart field Morphogenesis Congenital heart disease FGF signaling National Institutes of Health R35 HL135778 New York State Department of Health http://dx.doi.org/10.13039/100004856...

...Jyoti P. Satta; Riitta Lindström; Satu-Marja Myllymäki; Qiang Lan; Ewelina Trela; Renata Prunskaite-Hyyryläinen; Beata Kaczyńska; Maria Voutilainen; Satu Kuure; Seppo J. Vainio; Marja L. Mikkola ABSTRACT Branching morphogenesis is a characteristic feature of many essential organs, such as the lung...

... mechanisms. Finally, I discuss how these advances position regeneration as a more dynamic and variable process with expanded possibilities for morphogenesis compared with development. Collectively, these insights into mechanisms that orchestrate morphogenesis may reshape our understanding of the evolution...

... of their simultaneous growth and mechanical interactions are still unclear. Our study investigates how differential growth, tissue biophysical properties and mechanical interactions affect embryonic morphogenesis during axial extension using a 2D multi-tissue continuum-based mathematical model. Our model captures...

... and enrichment for actin along the baso-apical axis were dependent on CM-Wnts. Thus, CM-Wnts regulate cellular behaviors during calvarial morphogenesis for efficient apical expansion of calvarial osteoblasts. These findings also offer potential insights into the etiologies of calvarial dysplasias. Summary...

...://www.biologists.com/user-licence-1-1/ Highlighted Article: Heterogeneities in cell mechanics, growth, function and identity contribute to buckling in clavata mutant shoot apices. WUSCHEL CLAVATA Heterogeneities Morphogenesis Mechanics Buckling Arabidopsis École Normale Supérieure...

... a mechanism involving FGFR/ERK attenuation. Altogether, our results demonstrate no role for BMP4/SMAD4 in the first lineage decisions during mouse development. Rather, multi-pathway signaling among embryonic and extra-embryonic cell types drives epiblast morphogenesis postimplantation. * Present...

...Tejasvinee Atul Mody; Alexander Rolle; Nico Stucki; Fabian Roll; Ulrich Bauer; Kay Schneitz ABSTRACT Tissue morphogenesis remains poorly understood. In plants, a central problem is how the 3D cellular architecture of a developing organ contributes to its final shape. We address this question...

... organisms. In contrast, the physical mechanisms that shape cells and tissues have only recently started to emerge, in part thanks to new quantitative in vivo measurements of the physical quantities guiding morphogenesis. These data, combined with indirect inferences of physical characteristics, are starting...

...Guy B. Blanchard; Elena Scarpa; Leila Muresan; Bénédicte Sanson ABSTRACT The planar orientation of cell division (OCD) is important for epithelial morphogenesis and homeostasis. Here, we ask how mechanics and antero-posterior (AP) patterning combine to influence the first divisions after...

...Vanessa Barone; Antonio Tagua; Jesus Á. Andrés-San Román; Amro Hamdoun; Juan Garrido-García; Deirdre C. Lyons; Luis M. Escudero ABSTRACT Tissue morphogenesis is intimately linked to the changes in shape and organisation of individual cells. In curved epithelia, cells can intercalate along their own...

..., tissue folding is a crucial process that relies on a combination of local and tissue-wide mechanical forces. Here, we investigate the contribution of cell proliferation to epithelial morphogenesis using the Drosophila leg tarsal folds as a model. We reveal that tissue-wide compression forces generated...