...Virginia L. Pimmett; James McGehee; Antonio Trullo; Maria Douaihy; Ovidiu Radulescu; Angelike Stathopoulos; Mounia Lagha Morphogen gradients convey essential spatial information during tissue patterning. While both concentration and timing of morphogen exposure are crucial, how cells interpret...

...Rohit Krishnan Harish; Mansi Gupta; Daniela Zöller; Hella Hartmann; Ali Gheisari; Anja Machate; Stefan Hans; Michael Brand ABSTRACT Morphogen gradients impart positional information to cells in a homogenous tissue field. Fgf8a, a highly conserved growth factor, has been proposed to act...

... inhibition models of developmental processes . Math. Biosci. 90 , 265 - 286 . 10.1016/0025-5564(88)90070-3 Raspopovic , J. , Marcon , L. , Russo , L. and Sharpe , J. ( 2014 ). Digit patterning is controlled by a Bmp-Sox9-Wnt Turing network modulated by morphogen gradients...

...Hyung Chul Lee; Cato Hastings; Nidia M. M. Oliveira; Rubén Pérez-Carrasco; Karen M. Page; Lewis Wolpert; Claudio D. Stern ABSTRACT In many developing and regenerating systems, tissue pattern is established through gradients of informative morphogens, but we know little about how cells interpret...

...Shari Carmon; Felix Jonas; Naama Barkai; Eyal D. Schejter; Ben-Zion Shilo ABSTRACT Morphogen gradients are known to subdivide a naive cell field into distinct zones of gene expression. Here, we examine whether morphogens can also induce a graded response within such domains. To this end, we explore...

... tissues in the embryo. Hedgehog signaling Smoothened Gene-environment interactions Left-right patterning Morphogen Structural birth defects National Institutes of Health http://dx.doi.org/10.13039/100000002 GM118082 HL157103 HL142788 GM13251801 HL132024 American Heart...

...Jihyun Irizarry; Angelike Stathopoulos ABSTRACT Morphogen concentration changes in space as well as over time during development. However, how these dynamics are interpreted by cells to specify fate is not well understood. Here, we focus on two morphogens: the maternal transcription factors Bicoid...

... between cholesterol transport and morphogen signaling . Cell   138 , 1055 - 1056 . 10.1016/j.cell.2009.09.006 Belgacem , Y. H. and Borodinsky , L. N. ( 2011 ). Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord . Proc. Natl. Acad. Sci. USA...

... ligands for the proliferation of dorsal ependymal cells. Wnt Morphogen Spinal cord Roof plate Neural stem cell Regeneration Mouse During embryogenesis and homeostasis, secreted signaling proteins such as Wnts and BMPs regulate cell proliferation and differentiation in a spatially...

... status could add great diversity to its function in regulating the pattern of bone morphogenetic protein activity in cells, wings and embryos during Drosophila development. Glycosylation Bone morphogenetic protein Short gastrulation Chordin Morphogen Drosophila Glycosylation...

..., a transcription factor that patterns the Drosophila dorsal-ventral axis, accumulates at the embryo ventral midline. Here, model-guided experiments show that the inhibitor Cactus shuttles Dorsal to the ventral side. Morphogen Tissue patterning Mathematical modeling Dorsal Cactus Shuttling...

...William J. Bodeen; Suresh Marada; Ashley Truong; Stacey K. Ogden During development, extracellular cues guiding cell fate determination are provided by morphogens. One mechanism by which morphogens are proposed to traverse extracellular space is by traveling along specialized filopodia called...

... 2016. Published by The Company of Biologists Ltd 2016 Summary: This Meeting Review summarises the recent RIKEN-CDB Symposium 'Size in Development: Growth, Shape and Allometry', highlighting recent advances and open questions in the field. Hippo pathway Growth control Morphogen...

... . Shutdown of the first wave involves post-translational modulation of the maternal factor Bicoid. Bicoid Drosophila Transcription dynamics Mid-blastula transition Morphogen The transfer of developmental control from maternally deposited products to zygotically expressed products...

...Inna Averbukh; Danny Ben-Zvi; Siddhartha Mishra; Naama Barkai Morphogen gradients guide the patterning of tissues and organs during the development of multicellular organisms. In many cases, morphogen signaling is also required for tissue growth. The consequences of this interplay between growth...

...Ortrud Wartlick; Frank Jülicher; Marcos Gonzalez-Gaitan During morphogenesis, organs grow to stereotyped sizes, but growth control mechanisms are poorly understood. Here, we measured the signaling dynamics of the morphogen Dpp, one of several Drosophila factors controlling morphogenetic growth...

... mechanisms that disperse these morphogen signaling proteins remain controversial. Here, we review the conceptual background and evidence that establishes a fundamental and essential role for cytonemes as specialized filopodia that transport signaling proteins between signaling cells. This evidence suggests...

... for correspondence ( [email protected] ; [email protected] ) Competing interests The authors declare no competing financial interests. © 2013. Published by The Company of Biologists Ltd 2013 Bone morphogenetic proteins Mathematical modeling Morphogen Pattern formation Scale...

...Patrick Müller; Katherine W. Rogers; Shuizi R. Yu; Michael Brand; Alexander F. Schier The graded distribution of morphogens underlies many of the tissue patterns that form during development. How morphogens disperse from a localized source and how gradients in the target tissue form has been under...

...Samuel Tozer; Gwenvael Le Dréau; Elisa Marti; James Briscoe The conventional explanation for how a morphogen patterns a tissue holds that cells interpret different concentrations of an extrinsic ligand by producing corresponding levels of intracellular signalling activity, which in turn regulate...