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Keywords: mind bomb
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Journal Articles
Journal: Development
Development (2016) 143 (17): 3085–3096.
Published: 01 September 2016
...Miho Matsuda; Kinneret Rand; Greg Palardy; Nobuyuki Shimizu; Hiromi Ikeda; Damian Dalle Nogare; Motoyuki Itoh; Ajay B. Chitnis We identified Erythrocyte membrane protein band 4.1-like 5 (Epb41l5) as a substrate for the E3 ubiquitin ligase Mind bomb 1 (Mib1), which is essential for activation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (20): 3477–3487.
Published: 15 October 2010
... signaling pathways have a crucial role in directing the self-organization of this system (reviewed by Ma and Raible, 2009 ). mind bomb Posterior lateral line Neuromasts Morphogenesis Zebrafish Cadherins FGF signaling Lateral inhibition Immunohistochemistry...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (15): 2527–2537.
Published: 01 August 2010
... the patterning activities and structural integrity of the notochord. We found that Mind bomb (Mib) ubiquitylates Jagged 1 (Jag1) and is essential in the signal-emitting cells for Jag1 to activate Notch signalling. In zebrafish, loss- and gain-of-function analyses showed that Mib-Jag1-Notch signalling favours...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (6): 1111–1122.
Published: 15 March 2007
... in pronephric epithelial cells. Morpholino knockdown of either jagged 2 or notch3 , or mutation in mind bomb (in which Notch signaling is impaired), dramatically expands ciliogenic gene expression, whereas ion transporter expression is lost, indicating that pronephric cells are transfated to MCCs. Conversely...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (2): 295–305.
Published: 15 January 2007
...-Notch Pax2-5-8 Foxi1 Dlx Msx no isthmus ( pax2a ) mind bomb Sensory epithelia of the vertebrate inner ear consist of two cell types,hair cells and support cells. Both are produced from a prosensory equivalence group initially marked by expression of Atoh1 , a homolog...
Journal Articles
Journal: Development
Development (2005) 132 (18): 4041–4050.
Published: 15 September 2005
... activity. We also characterize a mutation in mib1 , a Drosophila homolog of mind bomb , another Delta-targeting ubiquitin ligase from zebrafish. Mib1 affects the signaling activity of Delta and Serrate in both lateral inhibition and wing dorsoventral boundary formation. Simultaneous absence of neuralized...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (15): 3459–3470.
Published: 01 August 2005
... mechanism essential for cell fate specification. Mind bomb 1 (Mib1) has been identified as a ubiquitin ligase that promotes the endocytosis of Delta. We now report that mice lacking Mib1 die prior to embryonic day 11.5, with pan-Notch defects in somitogenesis, neurogenesis,vasculogenesis and cardiogenesis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (10): 2319–2332.
Published: 15 May 2005
... is directly ubiquitinated by Drosophila and Xenopus Neuralized,and by zebrafish Mind bomb, two unrelated RING-type E3 ubiquitin ligases with common abilities to promote Delta endocytosis and signaling activity. Although orthologs of both Neuralized and Mind bomb are found in most metazoan organisms...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (5): 1093–1104.
Published: 01 March 2005
..., the Notch ligand DeltaD (Delta1 in the mouse) is expressed in cells of the secretory lineage. In an aei mutant, where DeltaD is defective, secretory cells are overproduced. In mind bomb ( mib ), where all Delta-Notch signalling is believed to be blocked,almost all the cells in the 3-day gut epithelium adopt...