...Miho Matsuda; Kinneret Rand; Greg Palardy; Nobuyuki Shimizu; Hiromi Ikeda; Damian Dalle Nogare; Motoyuki Itoh; Ajay B. Chitnis We identified Erythrocyte membrane protein band 4.1-like 5 (Epb41l5) as a substrate for the E3 ubiquitin ligase Mind bomb 1 (Mib1), which is essential for activation...

... , 118 - 132 . Choe E. A. , Liao L. , Zhou J. Y. , Cheng D. , Duong D. M. , Jin P. , Tsai L. H. , Peng J. ( 2007 ). Neuronal morphogenesis is regulated by the interplay between cyclin-dependent kinase 5 and the ubiquitin ligase mind bomb 1 . J. Neurosci...

... the patterning activities and structural integrity of the notochord. We found that Mind bomb (Mib) ubiquitylates Jagged 1 (Jag1) and is essential in the signal-emitting cells for Jag1 to activate Notch signalling. In zebrafish, loss- and gain-of-function analyses showed that Mib-Jag1-Notch signalling favours...

... in pronephric epithelial cells. Morpholino knockdown of either jagged 2 or notch3 , or mutation in mind bomb (in which Notch signaling is impaired), dramatically expands ciliogenic gene expression, whereas ion transporter expression is lost, indicating that pronephric cells are transfated to MCCs. Conversely...

... cells, as suggested by general elevation of Acridine Orange staining (not shown). We showed in another study that dying hair cells are often extruded from the otic vesicle to the underlying mesenchyme ( Kwak et al.,2006 ). This also occurs in mind bomb ( mib )mutants, which form supernumerary hair...

... activity. We also characterize a mutation in mib1 , a Drosophila homolog of mind bomb , another Delta-targeting ubiquitin ligase from zebrafish. Mib1 affects the signaling activity of Delta and Serrate in both lateral inhibition and wing dorsoventral boundary formation. Simultaneous absence of neuralized...

... mechanism essential for cell fate specification. Mind bomb 1 (Mib1) has been identified as a ubiquitin ligase that promotes the endocytosis of Delta. We now report that mice lacking Mib1 die prior to embryonic day 11.5, with pan-Notch defects in somitogenesis, neurogenesis,vasculogenesis and cardiogenesis...

... is directly ubiquitinated by Drosophila and Xenopus Neuralized,and by zebrafish Mind bomb, two unrelated RING-type E3 ubiquitin ligases with common abilities to promote Delta endocytosis and signaling activity. Although orthologs of both Neuralized and Mind bomb are found in most metazoan organisms...

..., the Notch ligand DeltaD (Delta1 in the mouse) is expressed in cells of the secretory lineage. In an aei mutant, where DeltaD is defective, secretory cells are overproduced. In mind bomb ( mib ), where all Delta-Notch signalling is believed to be blocked,almost all the cells in the 3-day gut epithelium adopt...

... from becoming hair cells, forcing them to be supporting cells instead. The zebrafish mind bomb mutant has abnormalities in the central nervous system, somites, and elsewhere, diagnostic of a failure of Delta-Notch signalling: in the CNS, it shows a neurogenic phenotype accompanied by misregulated delta...