... organoids, we identify microvilliation as a morphological feature that is enriched prior to fusion of cytotrophoblasts. Disruption of microvilli using an inhibitor of the actin-membrane cross-linker protein ezrin blocked cytotrophoblast fusion in both models. We provide evidence that cytotrophoblast...

...Flora Demouchy; Ophélie Nicolle; Grégoire Michaux; Anne Pacquelet ABSTRACT The kinase PAR-4/LKB1 is a major regulator of intestinal homeostasis, which prevents polyposis in humans. Moreover, its ectopic activation is sufficient to induce polarization and formation of microvilli-like structures...

...Aurélien Bidaud-Meynard; Flora Demouchy; Ophélie Nicolle; Anne Pacquelet; Shashi Kumar Suman; Camille N. Plancke; François B. Robin; Grégoire Michaux ABSTRACT The intestinal brush border is made of an array of microvilli that increases the membrane surface area for nutrient processing, absorption...

... architecture induces a conserved migratory and transcriptional response linked to vasculogenic mimicry . Nat. Commun.   8 , 1651 . 10.1038/s41467-017-01556-7 Viswanatha , R. , Bretscher , A. and Garbett , D. ( 2014 ). Dynamics of ezrin and EBP50 in regulating microvilli on the apical...

.... In particular, microvilli biogenesis through CD9 involvement appears to be a key event for successful gamete fusion, because CD9-disrupted oocytes produce short and sparse microvillous structures, resulting in almost no fusion ability with spermatozoa. In order to determine how CD9 and JUNO cooperate in gamete...

... microvilli (rhabdomeres) and a surrounding supporting membrane (stalk). By EMS-induced mutagenesis screening, we found that the F-Bin/Amphiphysin/Rvs (F-BAR) protein syndapin is essential for apical membrane segregation. The analysis of the super-resolution microscopy, STORM and the electron microscopy...

...C. Aimar ABSTRACT The microvilli (MV) of Pleurodeles (amphibian) eggs were examined following fertilization and compared with those of artificially activated eggs and enucleated eggs using scanning and transmission electron microscopy. The MV pattern in fertilized eggs was found to undergo a cyclic...

... of the crypt, a small population of cells contain a rudimentary terminal web and a few short microvilli with long rootlets. These microvilli appear to arise from bundles of actin filaments which nucleate on the plasma membrane. The microvilli apparently elongate via the addition of membrane supplied...

...Robert M. Ezzell; Mark M. Chafel; Paul T. Matsudaira ABSTRACT The apical surface of transporting epithelia is specially modified to absorb nutrients efficiently by amplifying its surface area as microvilli. Each microvillus is supported by an underlying core of bundled actin filaments. Villin...

...T. P. Fleming; S. J. Pickering; F. Qasim; B. Maro ABSTRACT The mechanism by which a surface pole of microvilli is generated in mouse 8-cell blastomeres has been investigated. 4-cell and 8-cell embryos (or cell couplets) were incubated for precise times during their respective cell cycles in medium...