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Keywords: microtubule
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Plant development
Journal: Development
Development (2024) 151 (20): dev202672.
Published: 1 May 2024
...Sarah T. Attrill; Liam Dolan ABSTRACT Microtubule organising centres (MTOCs) are sites of localised microtubule nucleation in eukaryotic cells. Regulation of microtubule dynamics often involves KATANIN (KTN): a microtubule severing enzyme that cuts microtubules to generate new negative ends...
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Reproductive biology
Journal: Development
Development (2024) 151 (5): dev201840.
Published: 13 March 2024
...-intrinsic sex determinant, foxl3 , triggers germline feminization by activating two genetic pathways that regulate folliculogenesis and meiosis. Here, we identified a pathway involving a dome-shaped microtubule structure that may be the basis of oocyte polarity. This structure was first established...
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Journal Articles
Journal: Development
Development (2022) 149 (22): dev200844.
Published: 16 November 2022
...Najat Dzaki; Shufeng Bu; Samuel Song Yuan Lau; Wei Lin Yong; Fengwei Yu ABSTRACT The evolutionarily conserved Glycogen Synthase Kinase 3β (GSK3β), a negative regulator of microtubules, is crucial for neuronal polarization, growth and migration during animal development. However, it remains unknown...
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Journal Articles
In collection:
Plant development
Journal: Development
Development (2022) 149 (15): dev200951.
Published: 4 August 2022
.... In this study, we classified the developmental processes during spermiogenesis in the liverwort Marchantia polymorpha according to changes in cellular and nuclear shapes and flagellar development. We then examined the remodeling of microtubules and the reorganization of endomembrane organelles. The results...
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Journal Articles
In collection:
Plant development
Journal: Development
Development (2022) 149 (12): dev200415.
Published: 21 June 2022
... the importance of the cytoskeleton, including actin filaments and microtubules, in rice development and environmental responses. Yet, reliable in vivo cytoskeleton markers are lacking in rice, which limits our knowledge of cytoskeletal functions in living cells. Therefore, we generated bright fluorescent marker...
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Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (3): dev171280.
Published: 4 February 2019
... 1 2019 © 2019. Published by The Company of Biologists Ltd 2019 http://www.biologists.com/user-licence-1-1/ Summary: The Rab23-Kif17 cargo complex associates with αTAT and Sirt2 to stabilize spindle microtubules, and transports the constituents of RhoA pathway to facilitate actin...
Journal Articles
Journal: Development
Development (2019) 146 (1): dev169664.
Published: 2 January 2019
... nutrients to the embryo. External yolk syncytial nuclei (e-YSN) undergo microtubule-dependent movements that distribute the nuclei over the large yolk mass. How e-YSN migration proceeds, and the role of the yolk microtubules, is not understood, but it is proposed that e-YSN are pulled vegetally...
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Neural development
Journal: Development
Development (2018) 145 (9): dev156950.
Published: 11 May 2018
... in their proximal regions, but how this spatial information is encoded is not clear. Dendrite severing is preceded by local breakdown of dendritic microtubules through PAR-1-mediated inhibition of Tau. Here, we investigated spatial aspects of microtubule breakdown during dendrite pruning. Live imaging...
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Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (6): dev158519.
Published: 16 March 2018
..., such as neuromuscular junctions. Despite the identification of numerous proteins that regulate synaptic actin and microtubule dynamics, the mechanisms of cytoskeletal control during terminal arbor formation have remained largely elusive. Here, we show that DAAM, a member of the formin family of cytoskeleton organizing...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (17): 3012–3021.
Published: 1 September 2017
...Andrew Muroyama; Terry Lechler Over the past several decades, numerous studies have greatly expanded our knowledge about how microtubule organization and dynamics are controlled in cultured cells in vitro . However, our understanding of microtubule dynamics and functions in vivo , in differentiated...
Journal Articles
Journal: Development
Development (2016) 143 (9): 1491–1501.
Published: 1 May 2016
... of core components of subdistal appendages (SDAs) and of recycling endosomes, which may be associated with premature extension of axonemal microtubules. Our data implicate CP110 in SDA assembly and ciliary vesicle docking, two requisite early steps in cilia formation. We suggest that CP110 has unique...
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Journal Articles
Journal Articles
Journal: Development
Development (2014) 141 (24): 4716–4728.
Published: 15 December 2014
... and through a Pak-independent non-canonical pathway to promote outgrowth. Whether this non-canonical pathway converges to promote Cofilin-dependent F-actin reorganization in axonal growth remains elusive. We demonstrate that Sickie, a homolog of the human microtubule-associated protein neuron navigator 2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (8): 1785–1795.
Published: 15 April 2013
... by a conserved core Wnt/PCP pathway. However, the hair cell-intrinsic polarity machinery is poorly understood. Recent findings implicate hair cell microtubules in planar polarization of hair cells. To elucidate the microtubule-mediated polarity pathway, we analyzed Lis1 function in the auditory sensory...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (21): 4661–4671.
Published: 1 November 2011
...Dikla Dubin-Bar; Amir Bitan; Anna Bakhrat; Simha Amsalem; Uri Abdu Asymmetrical localization of mRNA transcripts during Drosophila oogenesis determines the anteroposterior and dorsoventral axes of the Drosophila embryo. Correct localization of these mRNAs requires both microtubule (MT) and actin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (10): 2133–2142.
Published: 15 May 2011
... interests statement The authors declare no competing financial interests. 15 3 2011 © 2011. 2011 Seh1 (Nup44A) Mio NPC Nup107-160 Nucleoporin Oogenesis Meiosis Germline Drosophila Mtor (Tpr) Microtubule The pathways that control progression through the early...
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Journal Articles
Journal: Development
Development (2011) 138 (8): 1631–1641.
Published: 15 April 2011
... a mesenchymal-epithelial transition and form two apical domains at opposite ends. Extracellular lumens then form at the apical surfaces. We show that cortical actin and Ciona ezrin/radixin/moesin (ERM) are essential for lumen formation and that a polarized network of microtubules, which contributes to lumen...
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Journal Articles
Journal: Development
Development (2011) 138 (3): 543–552.
Published: 1 February 2011
... between the microtubule cytoskeleton and Wnt/PCP signaling during zebrafish gastrulation. First, we assessed the location of the centrosome/microtubule organizing center (MTOC) relative to the cell nucleus and the body axes, as a marker of cell polarity. The intracellular position of MTOCs was polarized...
Includes: Supplementary data