... allow significant remodeling of body plans during embryonic morphogenesis, regeneration and metamorphosis. Although the huge amount of organic matter that must be removed during these processes represents a potential source of nutrients, their further use by the organism has not yet been addressed. Here...

... whether GSK3β regulates neuronal pruning, which is a regressive process. Here, we report that the Drosophila GSK3β homologue Shaggy (Sgg) is cell-autonomously required for dendrite pruning of ddaC sensory neurons during metamorphosis. Sgg is necessary and sufficient to promote microtubule depolymerization...

... to be limited to control of microorganisms during metamorphosis. This has previously been shown by rescue of adult development in hemocyte-ablation models under germ-free conditions. Here, we show that hemocytes have an essential role in post-embryonic development beyond their ability to control the microbiota...

...Liang Yuh Chew; Jianzheng He; Jack Jing Lin Wong; Sheng Li; Fengwei Yu ABSTRACT During Drosophila metamorphosis, the ddaC dendritic arborisation sensory neurons selectively prune their larval dendrites in response to steroid hormone ecdysone signalling. The Nrf2-Keap1 pathway acts downstream...

... illustrations of X. laevis development from fertilization to metamorphosis, with additional views that were not available in the original collection. All the images are available on Xenbase, the Xenopus knowledgebase ( http://www.xenbase.org/entry/zahn.do ), for download and reuse under an attributable, non...

... revealed that homotetrameric ErGPCR-3 functions as a cell membrane receptor and increases 20E diffusion into cells to transmit the 20E signal and promote metamorphosis. * Author for correspondence ( [email protected] ) Handling Editor: Cassandra Extavour Competing interests The authors...

...Kentaro Kato; Minako Orihara-Ono; Takeshi Awasaki ABSTRACT Neural remodeling is essential for the development of a functional nervous system and has been extensively studied in the metamorphosis of Drosophila . Despite the crucial roles of glial cells in brain functions, including learning...

...Jiasheng Song; Wanwan Li; Haihong Zhao; Lulu Gao; Yuning Fan; Shutang Zhou ABSTRACT Krüppel-homolog 1 (Kr-h1), a zinc-finger transcription factor, inhibits larval metamorphosis and promotes adult reproduction by transducing juvenile hormone (JH). Although the transcriptional regulation of Kr-h1 has...

... remain poorly defined. To elucidate this process, we performed RNA-seq on isolated Drosophila larval and pupal neurons and found upregulated synaptic signaling and downregulated gene expression regulators as a result of normal neuronal metamorphosis. We further tested the role of alan shepard ( shep...

... metamorphosis. However, it is unknown whether the secretory pathway plays a role in dendrite pruning. Here, we show that the small GTPase Arf1, an important regulator of the secretory pathway, is specifically required for dendrite pruning of ddaC/D/E sensory neurons but dispensable for apoptosis of ddaF neurons...

... Developmental timing Ecdysone Metamorphosis Drosophila Multicellular organisms coordinate the timing of biological events during their development and throughout their life. The most characterized systems to determine biological timing are the circadian clock ( Allada and Chung, 2010 ) and clock...

..., these stem cells originate from within larger populations of intestinal progenitors that proliferate during the larval stage and form the adult intestine during metamorphosis. The origin of stem cells found in the excretory Malpighian tubules (‘renal stem cells’) has not been established. In this paper, we...

... processes during metamorphosis are poorly understood. Here, we demonstrate that the Dorsocross (Doc) T-box genes promote the progression of epithelial folds that not only separate the hinge and blade regions of the wing disc but also contribute to metamorphic development by changing cell shapes and bending...

...David J. Duffy; Günter Plickert; Timo Kuenzel; Wido Tilmann; Uri Frank We studied the role of Wnt signaling in axis formation during metamorphosis and regeneration in the cnidarian Hydractinia . Activation of Wnt downstream events during metamorphosis resulted in a complete oralization...

... are capable of cellulose biosynthesis. Cellulose synthase ( CesA ) gene products are present in filter-feeding structures of all tunicates and also regulate metamorphosis in the ascidian Ciona. Ciona CesA is proposed to have been acquired by lateral gene transfer from a prokaryote. We identified two CesA...

..., migrate and finally fuse to form the adult epidermis during metamorphosis. Here, we implicate Drosophila Activating transcription factor 3 (Atf3), the single ortholog of human ATF3 and JDP2 bZIP proteins, in abdominal morphogenesis. During the process of the epithelial cell replacement, transcription...

...Heather L. D. Brown; James W. Truman The adult central nervous system (CNS) of Drosophila is largely composed of relatively homogenous neuronal classes born during larval life. These adult-specific neuron lineages send out initial projections and then arrest development until metamorphosis, when...

.... For the first time, we demonstrate that JH counteracts MET and GCE to prevent caspase-dependent PCD in controlling fat body remodeling and larval-pupal metamorphosis in Drosophila . † Authors for correspondence: (e-mails: [email protected] ; [email protected] ) * These authors contributed equally...

... in the mutant line. At the larval stage,variable degrees of ectopic endoderm staining were observed in the homozygous mutants, indicating that loss of brachyury results in stochastic fate transformation. In post-metamorphosis mutants, a uniform defect in tail resorption was observed, together with variable...

... to produce stripes in the early larva. Dramatic changes to the pigment pattern occur subsequently during the larva-to-adult transformation, or metamorphosis. At this time, embryonic melanophores are replaced by newly differentiating metamorphic melanophores that form the adult stripes. Mutants with normal...