... activation in migrating mesoderm cells. The results support the model that Pyr acts as an instructive cue for mesoderm migration during gastrulation. Consistent with this function, mutations in pyr affect the normal segmental number of cardioblasts. Furthermore, Pyr is essential for the specification of even...

... during mesoderm migration. Genetic and biochemical interactions indicate that during mesoderm migration, Pbl functions by activating a Rac-dependent pathway. Furthermore,gain-of-function and rescue experiments suggest an important regulatory role of the C-terminal tail of Pbl for the selective activation...

... mesoderm migration axis formation The body of any multicellular animal that is not spherically or cylindrically symmetric is defined by three axes: anterior-posterior, dorsal-ventral and left-right. In animals that are bilaterally symmetric, the third axis (left-right) is inconsequential, being...