... medial ganglionic eminence (MGE) progenitors is required for maintaining their proliferative capacity and for the production of proper numbers of forebrain GABAergic interneurons. PRDM16 binds to cis-regulatory elements and represses the expression of region-specific neuronal differentiation genes...

...Tonggong Du; Qing Xu; Polloneal J. Ocbina; Stewart A. Anderson In the ventral telencephalon, the medial ganglionic eminence (MGE) is a major source of cortical interneurons. Expression of the transcription factor NKX2.1 in the MGE is required for the specification of two major subgroups of cortical...

... magnocellular complex Telencephalon Cortex Basal telencephalon medial ganglionic eminence Mouse Slit1 Slit2 netrin 1 Neurons are most frequently born at a distance from the place where they finally become integrated in a specific neuronal circuit, so that they have to migrate to reach...

... ; Sussel et al., 1999 ). In the telencephalon, loss of Nkx2-1 function causes a molecular transformation of the medial ganglionic eminence (MGE), which instead of producing its normal derivatives (e.g. globus pallidus), gives rise to LGE-like derivatives (e.g. striatum) ( Sussel et al., 1999...

... and the medial ganglionic eminence, the rostral telencephalon also gives rise to oligodendrocytes. We show that oligodendrocytes in the olfactory bulb are generated within the rostral pallium from ventricular progenitors characterized by the expression of Plp . We provide evidence that these Plp oligodendrocyte...

... of Lhx6 and Lhx7 in the oral aspect of the maxillary and mandibular processes. In the telencephalon, expression of both genes was predominantly localised in the developing medial ganglionic eminences, flanking a Fgf8-positive midline region. We suggest that Fgf8 and Lhx6 and Lhx7 are key components...