...Kristin M Hamre; Dan Goldowitz ABSTRACT The murine mutation meander tail (gene symbol: mea ) causes a near-total depletion of granule cells in the anterior lobe of the cerebellum, as well as aberrantly located Purkinje cells with misoriented dendrites and radial glia with stunted processes. Whether...

..., Wnt -3 expression was almost absent. In the meander tail mutant, in which the anterior cerebellar lobes lack granule cells, Wnt -3 expression was only detected in the normal posterior lobes. Since En genes are implicated in cell-cell interactions mediated by Wnt genes, we examined En- 2 /En- 2 mutant...