... contributions to zygotes and embryos, yet embryo defective ( emb ) mutants in the Columbia (Col) ecotype display early maternal effects. Here, we show that hybridization of Col with Landsberg erecta (L er ) or Cape Verde Islands (Cvi) ecotypes decreases the maternal effects of emb mutants. Reanalysis of Col/L...

... of the majority of these maternally expressed factors is not fully understood. By exploiting the biallelic editing ability of CRISPR-Cas9, we identify and characterize maternal-effect genes in a single generation, using a maternal crispant technique. We validated the ability to generate biallelic mutations...

... genetic screens have provided invaluable insights into the molecular regulation of embryonic development, including the essential contributions of some genes whose products must be provided to the transcriptionally silent early embryo for normal embryogenesis, called maternal-effect genes. However, other...

... ( Fig. 4 A). We conclude that Larp6 function is essential for normal chorion elevation, egg activation and morphogenesis of the early embryo. Fig. 3. Maternal effect of larp6a −/− and larp6a −/− ;larp6b −/− on oogenesis. (A) Bright-field images of 5 dpf larvae from the indicated...

.../501100001381 Agency for Science, Technology and Research 10.13039/501100001348 Biomedical Research Council KRAB-ZFP ZFP708 Epigenetics Inheritance Reprogramming DNA-methylation Development Trim28/Kap1 Maternal effect Summary: Analysis of the function...

... and cytokine signalling, which impact embryo survival. In addition, a significant proportion of Kdm4a-deficient oocytes displays a poor intrinsic ability to develop into blastocysts. These embryos cannot compete with healthy embryos for implantation in vivo , highlighting Kdm4a as a maternal effect gene. Thus...

... of these processes. Similarly, the maternal regulation of dorsoventral patterning, and in particular the maternal control of ventral tissue specification, is poorly understood. We identified split top , a recessive maternal-effect zebrafish mutant that disrupts embryonic patterning upstream of endogenous BMP...

... Gametophytes INCENP Maternal effect Seed development Sexual reproduction Cell cycle regulation WYRD The life cycle of plants alternates between a diploid sporophytic and a haploid gametophytic generation. In flowering plants (angiosperms) gametes are formed by sexually dimorphic...

...Sebastien Andreuzza; Jing Li; Anne-Elisabeth Guitton; Jean-Emmanuel Faure; Sandrine Casanova; Jin-Sup Park; Yeonhee Choi; Zhong Chen; Frédéric Berger Maternal effects are defined by mutations that affect the next generation when they are maternally inherited. To date, most indepth studies...

... reticulum. The genes involved in regulating the IP 3 -mediated Ca 2+ release during egg activation remain largely unknown. Here we report on a zebrafish maternal-effect mutant, brom bones , which is defective in the cytosolic Ca 2+ rise and subsequent egg activation events, including cortical granule...

...Quy A. Ngo; James M. Moore; Ramamurthy Baskar; Ueli Grossniklaus; Venkatesan Sundaresan Early seed development of sexually reproducing plants requires both maternal and paternal genomes but is prominently maternally influenced. A novel gametophytic maternal-effect mutant defective in early embryo...

... Epiboly Maternal effect Axis formation During early development, three distinct asymmetries are established in bilaterian embryos, which are precursors to the dorsoventral (DV) and anteroposterior (AP) body axes. Axis formation depends largely on maternal and zygotic genes and involves a series...

..., China Agricultural University, 2 Yuanmingyuan Xilu, Beijing 100094, People's Republic of China 25 11 2004 ©2005. 2005 Arabidopsis thaliana Female gametophyte Embryo sac development Fertilization Maternal effect Transposon insertion mutants The life cycle of plants...

... in the intracellular processing of guidance cues encountered by migrating cells and axons during development. * Author for correspondence (e-mail: [email protected] ) 7 9 2004 © 2004. 2004 mau-2 Migration Guidance slt-1 slit Caenorhabditis elegans Maternal effect Cell...

... ; Yahalom et al., 2001 ). COP9 signalosome Maternal effect Embryo development Oogenesis Drosophila © 2002. 2002 17 6 2002 †Authors for correspondence (e-mail: [email protected] and [email protected] ) Fig. 7. csn4 null and csn5 null mutants...

...Claire Bénard; Brent McCright; Yue Zhang; Stephanie Felkai; Bernard Lakowski; Siegfried Hekimi The Caenorhabditis elegans maternal-effect clk genes are involved in the temporal control of development and behavior. We report the genetic and molecular characterization of clk-2 . A temperature...

...Christina Kelly; Alvin J. Chin; Judith L. Leatherman,; David J. Kozlowski and; Eric S. Weinberg ABSTRACT We have identified and characterized a zebrafish recessive maternal effect mutant, ichabod , that results in severe anterior and dorsal defects during early development. The ichabod mutation...

..., so that accumulation of maternally derived gametophytic protein is likely to be responsible for the ‘maternal’ effect. Movie available on-line: http://www.biologists.com/Development/movies/dev0284.html * Author for correspondence (e-mail: [email protected] ) 06 04 2000 15 02...

... of Biologists 2000 Caenorhabditis elegans par-4 Asymmetry Polarity Maternal effect Serine-threonine kinase Asymmetries established during the first cell cycle of the C. elegans embryo are necessary for proper patterning and establishment of differential cell fates in the early...

..., D-30625 Hannover, Germany † Author for correspondence (e-mail: [email protected] ) 12 02 1998 © 1998 by Company of Biologists 1998 Drosophila Sex determination Oogenesis Autoregulation Maternal effect Sxl virilizer ( vir ) Sex-lethal (Sxl) is the key...