... in the maintenance of vascular homeostasis; however, in vivo molecular and cellular mechanisms underlying mural cell development remain unclear. In this study, we found that macrophages played a crucial role in TGFβ-dependent pericyte-to-VSMC differentiation during retinal vasculature development. In mice...

...Sally W. Feng; Tanya M. North; Peri Wivell; Andrew Pletcher; Anastas Popratiloff; Maho Shibata ABSTRACT Tissue-resident macrophages contribute to the organogenesis of many tissues. Growth of the prostate is regulated by androgens during puberty, yet androgens are considered immune suppressive...

... that rfem.L and/or rfem.S are required for tail regeneration. Single-cell RNA sequencing (scRNA-seq) revealed that rfem.L and rfem.S are expressed in a subset of leukocytes with a macrophage-like gene expression profile. KD of colony-stimulating factor 1 ( csf1 ), which is essential for macrophage...

.... Summary: Secretion of the previously uncharacterized protein 4931414P19Rik by neural progenitors is crucial for mediating neuro-immune crosstalk and for regulating neuronal migration during brain development. Brain development Neuronal migration Microglia Macrophage Chemoattraction...

... and repair has been documented over many decades, recent studies have begun to define a more direct role for specific immune cells in the modulation of tissue repair. One particular cell of the innate immune system, the macrophage, has emerged as a central integrator of the complex molecular processes...

...Christopher Zhe Wei Lee; Florent Ginhoux ABSTRACT Although best known for their phagocytic and immunological functions, macrophages have increasingly been recognised as key players in the development, homeostasis and regeneration of their host tissues. Early during development, macrophages...

... to injury. Here, we monitored osteoblast-immune cell interactions in bone, a tissue which is particularly difficult to in vivo image in tetrapod species. Ablation of individual osteoblasts leads to recruitment of neutrophils and macrophages in varying numbers, depending on the extent of the initial insult...

... expansion of tissue macrophage populations in most organs. Bone marrow cells from Csf1r E631K/+ mice were resistant to CSF1 stimulation in vitro , and Csf1r E631K/+ mice were unresponsive to administration of a CSF1-Fc fusion protein, which expanded tissue macrophage populations in controls. In the brain...

... injury model to investigate inflammatory and regenerative responses in larval zebrafish using heartbeat-synchronised light-sheet fluorescence microscopy. We used this model to test two clinically approved CDK9 inhibitors, AT7519 and flavopiridol, examining their effects on neutrophils, macrophages...

...Gillian J. Wilson; Ayumi Fukuoka; Samantha R. Love; Jiwon Kim; Marieke Pingen; Alan J. Hayes; Gerard J. Graham ABSTRACT Macrophages are key regulators of developmental processes, including those involved in mammary gland development. We have previously demonstrated that the atypical chemokine...

...Marine Theret; Remi Mounier; Fabio Rossi ABSTRACT The discovery of new non-canonical (i.e. non-innate immune) functions of macrophages has been a recurring theme over the past 20 years. Indeed, it has emerged that macrophages can influence the development, homeostasis, maintenance and regeneration...

...Jennifer Simkin; Mimi C. Sammarco; Luis Marrero; Lindsay A. Dawson; Mingquan Yan; Catherine Tucker; Alex Cammack; Ken Muneoka In mammals, macrophages are known to play a major role in tissue regeneration. They contribute to inflammation, histolysis, re-epithelialization, revascularization and cell...

... that the innate immune system can be studied in isolation of the adaptive immune system, because the latter is not functional at early larval stages ( Danilova and Steiner, 2002 ; Lam et al., 2004 ). Hence, microglia/macrophages are positive regulators of lesion-induced neurogenesis in the lesioned adult...

...Angela C. L. Chua; Leigh J. Hodson; Lachlan M. Moldenhauer; Sarah A. Robertson; Wendy V. Ingman Each ovarian cycle, the mammary gland epithelium rotates through a sequence of hormonally regulated cell proliferation, differentiation and apoptosis. These studies investigate the role of macrophages...

...Ulrich Tigges; Elizabeth Gore Hyer; Jeffrey Scharf; William B. Stallcup Vessel-like networks are quickly formed in subcutaneous FGF2-supplemented Matrigel plugs by two cell types: NG2 + pericytes and F4/80 + macrophages. Although not detected in these networks until 7 days after plug implantation...

...Sujata Rao; Ivan B. Lobov; Jefferson E. Vallance; Kaoru Tsujikawa; Ichiro Shiojima; Shailaja Akunuru; Kenneth Walsh; Laura E. Benjamin; Richard A. Lang Macrophages have a critical function in the recognition and engulfment of dead cells. In some settings, macrophages also actively signal programmed...

...Sven Huelsmann; Christina Hepper; Daniele Marchese; Christian Knöll; Rolf Reuter In Drosophila embryos, macrophages originate from the cephalic mesoderm and perform a complex migration throughout the entire embryo. The molecular mechanisms regulating this cell migration remain largely unknown. We...

..., 2002 ). Both EH and LGH differentiate into podocytes,crystal cells and plasmatocytes ( Lanot et al., 2001 ). Hemocytes of both populations have the capability to adopt macrophage characteristics. However, despite all similarities, the history of the two populations is quite different, as they originate...

... that enter tissues at different stages of development. In this paper we identify two such cell types, macrophages and eosinophils, that are recruited around the growing terminal end buds (TEBs) during postnatal development. An important role for leukocytes in mammary gland ductal outgrowth is first...

... as in-situ hybridization for the expression of two new hemopoietic marker genes, draculin and leucocyte-specific plastin , we show that macrophages appear in the embryo at least as early as erythroid cells, but originate from ventro-lateral mesoderm situated at the other end of the embryo, just anterior...