... . To elucidate the molecular pathways triggered by Par-1, we have performed a genome-wide,high-throughput screen for Par-1 targets. Among the targets identified in this screen was Exuperantia (Exu), a mediator of bicoid mRNA localisation. We show that Exu is a phosphoprotein whose phosphorylation is dependent...

... that localised pair-rule transcripts target their proteins in close proximity to the nuclei and increase the reliability of the segmentation process by augmenting gene activity. Our data suggest that mRNA localisation signals in pair-rule transcripts affect nuclear protein uptake and thereby adjust gene activity...

... back to the oocyte. We report that Drosophila Merlin is specifically required only within the posterior follicle cells to initiate axis formation. Merlin mutants show defects in nuclear migration and mRNA localisation in the oocyte. Merlin is not required to specify posterior follicle cell identity...

..., San Francisco, California 94143, USA 07 09 1990 © 1990 by Company of Biologists 1990 cyclins mRNA localisation microtubules polar granules germ cells Drosophila The cyclins are a family of proteins that accumulate during interphase, and are then rapidly degraded...