... with an increase of the proteins they encode. In contrast, transcription of liver function-related mRNAs was lower in Cnot3 −/− livers. We detect efficient suppression of Cnot3 protein postnatally, demonstrating the crucial contribution of mRNA decay to postnatal liver functional maturation. * Authors...

... comparisons, between WT and null or ‘effective null’ animals, as well as in mRNA decay assays in TSCs. These and other analyses allowed us to generate lists of high probability target transcripts for ZFP36L3. An example of one of the top ranked transcripts was the Hbegf mRNA, which was significantly...