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Keywords: mRNA decay
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Journal Articles

Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes

Open Access
Toru Suzuki, Chisato Kikuguchi, Saori Nishijima, Takeshi Nagashima, Akinori Takahashi, Mariko Okada, Tadashi Yamamoto
Journal: Development
Development (2019) 146 (4): dev168146.
https://doi.org/10.1242/dev.168146
Published: 15 February 2019
... with an increase of the proteins they encode. In contrast, transcription of liver function-related mRNAs was lower in Cnot3 −/− livers. We detect efficient suppression of Cnot3 protein postnatally, demonstrating the crucial contribution of mRNA decay to postnatal liver functional maturation. * Authors...
View articletitled, Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes
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Includes: Supplementary data
Journal Articles

Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism

Free
Deborah J. Stumpo, Carol S. Trempus, Charles J. Tucker, Weichun Huang, Leping Li, Kimberly Kluckman, Donna M. Bortner, Perry J. Blackshear
Journal: Development
Development (2016) 143 (8): 1424–1433.
https://doi.org/10.1242/dev.130369
Published: 15 April 2016
... of Biologists Ltd 2016 Summary: ZFP36L3-deficient mice have fewer offspring than normal and increased placental expression of many potential target genes, including genes essential for placenta function. Deadenylation mRNA binding proteins mRNA decay Placenta Zinc finger proteins...
View articletitled, Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism
Open the PDF for Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism in another window
Includes: Supplementary data