... Aulehla , A. and Johnson , R. L. ( 1999 ). Dynamic expression of lunatic fringe suggests a link between notch signaling and an autonomous cellular oscillator driving somite segmentation . Dev. Biol. 207 , 49 - 61 . 10.1006/dbio.1998.9164 Aulehla , A. , Wiegraebe , W...

...Dustin R. Williams; Emily T. Shifley; Kara M. Braunreiter; Susan E. Cole Vertebrate somitogenesis is regulated by a segmentation clock. Clock-linked genes exhibit cyclic expression, with a periodicity matching the rate of somite production. In mice, lunatic fringe ( Lfng ) expression oscillates...

... for boundary formation. To clarify this discrepancy in our current study, we created a transgenic mouse lacking NICD boundaries in the anterior PSM but retaining Notch signal oscillation in the posterior PSM by manipulating the expression pattern of a Notch modulator, lunatic fringe. In this mouse, clearly...

... pronephric expression of lunatic fringe and radical fringe that is temporally and spatially appropriate for a role in regulating Notch signalling in the dorso-anterior region of the pronephros anlagen. On the basis of these results, along with data from previous publications, we propose a mechanism by which...

...Emily T. Shifley; Kellie M. VanHorn; Ariadna Perez-Balaguer; John D. Franklin; Michael Weinstein; Susan E. Cole The Notch pathway plays multiple roles during vertebrate somitogenesis,functioning in the segmentation clock and during rostral/caudal (R/C) somite patterning. Lunatic fringe ( Lfng...

...Katherine L. Hahn; Joshua Johnson; Brian J. Beres; Sheena Howard; Jeanne Wilson-Rawls We have demonstrated that Notch genes are expressed in developing mammalian ovarian follicles. Lunatic fringe is an important regulator of Notch signaling. In this study, data are presented that demonstrate...

... and epithelialized. We have further studied the molecular mechanisms underlying these interactions by focusing on Lunatic fringe, a modulator of Notch signaling, which is expressed in the region of the presumptive boundary. By combining DNA in ovo electroporation and embryonic transplantation techniques we have...

...Caroline Jouve; Tadahiro Iimura; Olivier Pourquie Vertebrate somitogenesis is associated with a molecular oscillator, the segmentation clock, which is defined by the periodic expression of genes related to the Notch pathway such as hairy1 and hairy2 or lunatic fringe (referred to as the cyclic...

... are not able to organise themselves into somites and lose the expression of genes known to be important for vertebrate segmentation, such as Delta-1 , Notch-1 , paraxis , hairy1 , hairy2 and lunatic fringe . †Author for correspondence (e-mail: [email protected] ) 14 9 2001 It is now...

... in the Notch signalling pathway was altered, including Delta-like3, Hes5 , lunatic fringe ( Lfng ) and Mesp2 . Thus, Ps1-dependent activation of the Notch pathway is essential for caudal half somite development. We observed defects in Notch signalling in both the caudal and rostral region of the presomitic...

... evidence indicates that a molecular oscillator, the ‘segmentation clock’, operates in the presomitic mesoderm (PSM) to direct periodic expression of c-hairy1 and lunatic fringe (l-fng) . Here, we report the identification and characterisation of a second avian hairy -related gene, c-hairy2 , which also...

... outgrowth, at around stage 26, and includes lunatic fringe (lfng), Xwnt3a and Xhox3 . Our results showed that the early and late gene domains together defined seven distinct regions of the tail bud, and this has now been increased to ten regions following the study of additional genes ( Gawantka et al...