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Keywords: liver
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Journal Articles
Journal: Development
Development (2022) 149 (16): dev199615.
Published: 18 August 2022
..., such as the liver, and have tailored hyperspectral protocols for time-efficient acquisition. Combining FRaeppli with polarity markers revealed previously unknown canalicular topologies between differentiating hepatocytes, reminiscent of the mammalian liver, suggesting common developmental mechanisms...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (17): dev199814.
Published: 3 September 2021
...Stephanie A. Campbell; Tabea L. Stephan; Jeremy Lotto; Rebecca Cullum; Sibyl Drissler; Pamela A. Hoodless ABSTRACT Liver development is controlled by key signals and transcription factors that drive cell proliferation, migration, differentiation and functional maturation. In the adult liver, cell...
Journal Articles
Journal: Development
Development (2018) 145 (19): dev168658.
Published: 11 October 2018
...Gabriel K. El Sebae; Joseph M. Malatos; Mary-Kate E. Cone; Siyeon Rhee; Jesse R. Angelo; Jesse Mager; Kimberly D. Tremblay ABSTRACT The definitive endoderm (DE) is the embryonic germ layer that forms the gut tube and associated organs, including thymus, lungs, liver and pancreas. To understand how...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (9): dev159095.
Published: 25 April 2018
... in physiological functions and regeneration of the liver. However, the processes of development and reconstruction of the intrahepatic nerve network and its underlying mechanisms remain unknown. Here, we demonstrate that neural class III β-tubulin (TUBB3) + nerve fibers are not distributed in intrahepatic tissue...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (18): 3126–3137.
Published: 15 September 2015
... Endoderm Foregut Liver β-cells Transcription factor The pancreas is a composite organ derived from two buds, dorsal and ventral, that arise from either side of the distal foregut endoderm. It contains a distinctive combination of cell lineages. The exocrine tissue comprises acinar cells...
Journal Articles
Journal: Development
Development (2014) 141 (3): 538–547.
Published: 1 February 2014
...Asha Seth; Jianming Ye; Nanjia Yu; Fanny Guez; David C. Bedford; Geoffrey A. Neale; Sabine Cordi; Paul K. Brindle; Frederic P. Lemaigre; Klaus H. Kaestner; Beatriz Sosa-Pineda The liver has multiple functions that preserve homeostasis. Liver diseases are debilitating, costly and often result...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2669–2679.
Published: 1 July 2013
...Joseph J. Lancman; Natasha Zvenigorodsky; Keith P. Gates; Danhua Zhang; Keely Solomon; Rohan K. Humphrey; Taiyi Kuo; Linda Setiawan; Heather Verkade; Young-In Chi; Ulupi S. Jhala; Christopher V. E. Wright; Didier Y. R. Stainier; P. Duc Si Dong Although the liver and ventral pancreas are thought...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (9): 1912–1918.
Published: 1 May 2013
... specific recognition protein 1a (Ssrp1a), which, together with Spt16, forms the FACT heterodimer. Focussing on the liver and eye, we show that zygotic Ssrp1a is essential for proliferation and differentiation during organogenesis. Specifically, gene expression indicative of progressive organ...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (18): 3363–3372.
Published: 15 September 2012
.... We show that pancreatic progenitor-specific ablation of Sox9 during early pancreas development causes pancreas-to-liver cell fate conversion. Sox9 deficiency results in cell-autonomous loss of the fibroblast growth factor receptor (Fgfr) 2b, which is required for transducing mesenchymal Fgf10 signals...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (16): 3557–3568.
Published: 15 August 2011
...Morgane Poulain; Elke A. Ober The vertebrate liver, pancreas and lung arise in close proximity from the multipotent foregut endoderm. Tissue-explant experiments uncovered instructive signals emanating from the neighbouring lateral plate mesoderm, directing the endoderm towards specific organ fates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (1): 139–148.
Published: 1 January 2011
... for this process. We found that hepatic expression of erythropoietin (EPO), a secreted factor implicated in myocardial expansion, is dependent on both Raldh2 and Rxra . Chromatin immunoprecipitation studies support Epo as a direct target of RA signaling in embryonic liver. Treatment of an epicardial cell line...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (10): 1727–1739.
Published: 15 May 2009
...Yiwei Zong; Archana Panikkar; Jie Xu; Aline Antoniou; Peggy Raynaud; Frederic Lemaigre; Ben Z. Stanger In the mammalian liver, bile is transported to the intestine through an intricate network of bile ducts. Notch signaling is required for normal duct formation, but its mode of action has been...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (9): 1589–1595.
Published: 1 May 2008
...Atsushi Suzuki; Sayaka Sekiya; Dirk Büscher; Juan Carlos Izpisúa Belmonte; Hideki Taniguchi Although the T-box family of transcription factors function in many different tissues, their role in liver development is unknown. Here we show that Tbx3 , the T-box gene that is mutated in human ulnar...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (2): 387–399.
Published: 15 January 2008
... been implicated in a wide range of human diseases. We identify the zebrafish mutant lbk as a novel model for such disorders. lbk displays hypopigmentation of skin melanocytes and the retinal pigment epithelium (RPE), an absence of iridophore reflections, defects in internal organs (liver, intestine...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (12): 2207–2217.
Published: 15 June 2007
...Valérie A. McLin; Scott A. Rankin; Aaron M. Zorn The liver and pancreas are specified from the foregut endoderm through an interaction with the adjacent mesoderm. However, the earlier molecular mechanisms that establish the foregut precursors are largely unknown. In this study, we have identified...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (10): 2041–2051.
Published: 15 May 2006
..., the earliest known lymphoid event, first occurred around E10.5 within the embryos. RAG1/GFP + cells appeared in the liver at E11.0 and progenitors with B and/or T lineage potential were enumerated at subsequent developmental stages. 8 3 2006 © 2006. 2006 Table 1. Potential for RAG-1/GFP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (17): 4005–4014.
Published: 1 September 2005
... is required for development of the intestine, liver, pancreas and swim bladder. Therefore, a single transcription factor regulates the formation of many organs. Gata6 is a closely related transcription factor with an overlapping expression pattern. We show that zebrafish depleted of Gata6 show defects...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2005) 132 (4): 763–774.
Published: 15 February 2005
..., revealed GATA5 and 6 as the most critical for the development of the gut and the liver. ‡ Author for correspondence (e-mail: roger.patient@imm.ox.ac.uk ) * Present address: School of Medical Sciences, Cell and Developmental Biology Research Programme, Institute of Medical Sciences, University...
Journal Articles
Journal: Development
Development (2005) 132 (1): 35–47.
Published: 1 January 2005
... of a pulmonary cell fate using embryo tissue explants. We show that NKX2.1, an early transcription factor crucial for lung development, is expressed in the ventral foregut endoderm shortly after albumin and Pdx1, early markers of the liver and pancreas lineages, respectively. Similar to hepatic specification...