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1-19 of 19
Keywords: lineage specification
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Journal Articles
Journal:
Development
Development (2023) 150 (18): dev201494.
Published: 25 September 2023
.... , Dirks , P. B. , He , H. H. and Kim , T.-H. (2019). Gastrointestinal transcription factors drive lineage-specific developmental programs in organ specification and cancer . Sci. Adv. 5 , eaax8898 . 10.1126/sciadv.aax8898 Gao , S. , Yan , L. , Wang , R. , Li , J...
Journal Articles
In collection:
Highlights from our Research Reports section
Claudia Gerri, Afshan McCarthy, Gwen Mei Scott, Marius Regin, Panagiotis Stamatiadis, Sophie Brumm, Claire S. Simon, Janet Lee, Cristina Montesinos, Caroline Hassitt, Sarah Hockenhull, Daniel Hampshire, Kay Elder, Phil Snell, Leila Christie, Ali A. Fouladi-Nashta, Hilde Van de Velde, Kathy K. Niakan
Journal:
Development
Development (2023) 150 (8): dev201112.
Published: 20 April 2023
... differences in the timing or mechanism of lineage specification that necessitates further investigation. Consistent with this, blastocyst chimera, re-aggregation experiments and live-imaging analysis suggest that the timing of irreversible commitment of the TE occurs earlier in the mouse compared with human...
Includes: Supplementary data
Journal Articles
Clara Munger, Timo N. Kohler, Erin Slatery, Anna L. Ellermann, Sophie Bergmann, Christopher A. Penfold, Ioakeim Ampartzidis, Yutong Chen, Florian Hollfelder, Thorsten E. Boroviak
Journal:
Development
Development (2022) 149 (20): dev200263.
Published: 20 September 2022
... platform to decipher the essential cues for embryonic and extraembryonic lineage specification in primate embryogenesis. Agarose microgels Amnion Embryonic disc Epiblast Lineage specification Primate embryogenesis Wellcome Trust http://dx.doi.org/10.13039/100010269 WTRG89228...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2021) 148 (1): dev193789.
Published: 7 January 2021
... that the PS elongates over time in a proximal to distal fashion suggests that mesoderm and DE progenitor specification is also temporally separated. To test the temporal sequence of lineage specification downstream of Eomes , we performed time-dependent genetic lineage tracing using a tamoxifen-inducible...
Includes: Supplementary data
Journal Articles
Mammary development in the embryo and adult: new insights into the journey of morphogenesis and commitment
Open Access
Journal:
Development
Development (2020) 147 (22): dev169862.
Published: 15 November 2020
... benefits of milk including the provision of passive immunity and a microbiome and, in humans, the psychosocial benefits of breastfeeding. In this Review, we outline the various stages of mammary gland development in the mouse, with a particular focus on lineage specification and the new insights that have...
Journal Articles
Journal:
Development
Development (2019) 146 (7): dev172916.
Published: 3 April 2019
... this formative transition highlights dynamic changes in gene expression, which affect many cellular properties including metabolism and epithelial features. Notably, naïve pluripotency factors are exchanged for postimplantation factors, but competent cells remain devoid of lineage-specific transcription...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2018) 145 (20): dev164384.
Published: 22 October 2018
... and are often associated with developmental diseases in humans. In this Primer, we discuss the unique and redundant functions of GATA proteins in tissue morphogenesis, with an emphasis on their regulation of lineage specification and early organogenesis. * These authors contributed equally to this work...
Journal Articles
Carla Mulas, Gloryn Chia, Kenneth Alan Jones, Andrew Christopher Hodgson, Giuliano Giuseppe Stirparo, Jennifer Nichols
Journal:
Development
Development (2018) 145 (12): dev159103.
Published: 18 June 2018
... a conditional deletion system to investigate embryonic patterning and lineage specification in response to loss of Oct4. We first observe ectopic expression of Nanog in Oct4-negative postimplantation epiblast cells. The expression domains of lineage markers are subsequently disrupted. Definitive endoderm...
Includes: Supplementary data
Journal Articles
Rute A. Tomaz, Jennifer L. Harman, Donja Karimlou, Lauren Weavers, Lauriane Fritsch, Tony Bou-Kheir, Emma Bell, Ignacio del Valle Torres, Kathy K. Niakan, Cynthia Fisher, Onkar Joshi, Hendrik G. Stunnenberg, Edward Curry, Slimane Ait-Si-Ali, Helle F. Jørgensen, Véronique Azuara
Journal:
Development
Development (2017) 144 (4): 567–579.
Published: 15 February 2017
... demethylases cooperate in promoting mouse embryonic stem cell (ESC) identity. However, little is known about their importance at the exit of ESC pluripotency. Here, we reveal that Jmjd2c facilitates this process by stabilising the assembly of mediator-cohesin complexes at lineage-specific enhancers...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2017) 144 (3): 365–373.
Published: 1 February 2017
... Epiblast Lineage specification Developmental potential Summary: This Hypothesis article poses that a third state of pluripotency, called formative pluripotency, exists between the naïve and primed states, and is enabling for the execution of pluripotency. © 2017. Published by The Company...
Journal Articles
Journal:
Development
Development (2016) 143 (20): 3700–3710.
Published: 15 October 2016
... financial interests. 8 3 2016 17 8 2016 © 2016. Published by The Company of Biologists Ltd 2016 Highlighted Article: Somatic progenitor cell populations in the mouse testis are defined by progressive lineage-specific acquirement of WT1, HES1, SOX9 and GLI1 beginning at the time...
Includes: Supplementary data
Journal Articles
Maryna Panamarova, Andy Cox, Krzysztof B. Wicher, Richard Butler, Natalia Bulgakova, Shin Jeon, Barry Rosen, Rho H. Seong, William Skarnes, Gerald Crabtree, Magdalena Zernicka-Goetz
Journal:
Development
Development (2016) 143 (8): 1271–1283.
Published: 15 April 2016
... that BAF155, a major BAF complex subunit, regulates the assembly of the BAF complex in vivo and regulates lineage specification of the mouse blastocyst. We find that associations of BAF155 with other BAF complex subunits become enriched in extra-embryonic lineages just prior to implantation. This enrichment...
Includes: Supplementary data
Journal Articles
Atypical protein kinase C couples cell sorting with primitive endoderm maturation in the mouse blastocyst
Open Access
Journal:
Development
Development (2013) 140 (21): 4311–4322.
Published: 1 November 2013
... This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Lineage specification...
Includes: Supplementary data
Journal Articles
Joanna B. Grabarek, Krystyna Żyżyńska, Néstor Saiz, Anna Piliszek, Stephen Frankenberg, Jennifer Nichols, Anna-Katerina Hadjantonakis, Berenika Plusa
Journal:
Development
Development (2012) 139 (1): 129–139.
Published: 1 January 2012
... and preservation of the pluripotent foetal lineage. * Author for correspondence ([email protected]) Competing interests statement The authors declare no competing financial interests. 27 10 2011 © 2012. Lineage specification Mouse blastocyst ICM Primitive...
Includes: Supplementary data
Journal Articles
Guangming Wu, Luca Gentile, Takuya Fuchikami, Julien Sutter, Katherina Psathaki, Telma C. Esteves, Marcos J. Araúzo-Bravo, Claudia Ortmeier, Gaby Verberk, Kuniya Abe, Hans R. Schöler
Journal:
Development
Development (2010) 137 (24): 4159–4169.
Published: 15 December 2010
... statement 11 10 2010 © 2010. Cdx2 Trophectoderm Lineage specification Preimplantation mouse embryos The first visible cell lineage split in the development of the mammalian embryo occurs during blastulation. The cells of the inner part of the blastocyst, called...
Includes: Supplementary data
Journal Articles
Journal:
Development
Development (2010) 137 (23): 3953–3963.
Published: 1 December 2010
... mutant embryos from 34 litters were included. * Author for correspondence ([email protected]) Competing interests statement 22 9 2010 © 2010. Klf5 Trophectoderm Epiblast Embryonic stem cells Pluripotency Primitive endoderm Lineage specification...
Includes: Supplementary data
Journal Articles
Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst
Free
Journal:
Development
Development (2008) 135 (18): 3081–3091.
Published: 15 September 2008
... reporter under the control of Pdgfra regulatory elements with the analysis of lineage-specific markers, we investigated the events leading to PrE and EPI lineage segregation in the mouse, and correlated our findings using an embryo staging system based on total cell number. Before blastocyst formation...
Includes: Multimedia, Supplementary data
Journal Articles
Journal:
Development
Development (2007) 134 (23): 4219–4231.
Published: 1 December 2007
... Institute for Molecular Biomedicine, Mammalian Development Laboratory, Münster, Germany 31 8 2007 © 2007. 2007 Embryonic patterning Lineage specification Mouse pre-implantation embryos Mammalian embryonic development is characterized by an initial pre-implantation phase...
Includes: Multimedia, Supplementary data
Journal Articles
Granule cell specification in the developing mouse brain as defined by expression of the zinc finger transcription factor RU49
Available to Purchase
Journal:
Development
Development (1996) 122 (2): 555–566.
Published: 1 February 1996
... for correspondence 07 11 1995 © 1996 by Company of Biologists 1996 RU49 cerebellum granule cells transcription factor lineage specification mouse brain zinc finger The role of cell-type-specific transcription factors in lineage specification during invertebrate development (Jan...