... is determined by the cell number and cell dispersion of cerebellar granule cell precursor clones, which vary on different sides of the lineage boundary between lobules. Foliation Lineage restriction Lobules Morphogenesis Polarized growth Engrailed mutants Mouse In order to produce an organ...

... that regulates this lineage restriction in established ES cells or the epiblast. Here, we have used a combination of bioinformatic and functional genomic approaches to address fundamental questions about the first lineage restriction in the mouse. Specifically, what other factors act downstream of Tead4...

... precursors for different thalamic nuclei display temporally distinct Gbx2 expression patterns. Gbx2 -expressing cells and their descendents form sharp lineage-restriction boundaries delineating the thalamus from the pretectum,epithalamus and prethalamus, revealing multiple compartmental boundaries within...

... their position with the expression of a midbrain marker, we demonstrate that midbrain and hindbrain cells arise from two distinct cell populations. Single cell labeling and analysis of the distribution of their progeny shows that lineage restriction is probably established during late gastrulation stages. Our...

... compartment lineage restriction chick embryo limb development A fundamental question in the development of the vertebrate body plan is what regulates dorso-ventral pattern, and this is important with respect to limb number, type and position. Limb position must be specified in relation to both...