... migration C. elegans embryo Lineage National Institutes of Health R01GM097576 P30CA008748 Planar cell polarity (PCP) is a conserved mechanism to coordinate polarity of individual cells across a tissue ( Devenport, 2014 ). Coordination is controlled by the asymmetric distribution...

... ). Urogenital development in Pallister-Hall syndrome is disrupted in a cell-lineage-specific manner by constitutive expression of GLI3 repressor . Hum. Mol. Genet. 25 , 437 - 447 . 10.1093/hmg/ddv483 Bohnenpoll , T. , Bettenhausen , E. , Weiss , A.-C. , Foik , A. B. , Trowe , M...

...Neda Masoudi; Eviatar Yemini; Ralf Schnabel; Oliver Hobert ABSTRACT Cells of the same type can be generated by distinct cellular lineages that originate in different parts of the developing embryo (‘lineage convergence’). Several Caenorhabditis elegans neuron classes composed of left/right...

...Jie Li; Julie Gordon; Edward L. Y. Chen; Shiyun Xiao; Luying Wu; Juan Carlos Zúñiga-Pflücker; Nancy R. Manley ABSTRACT The cortical and medullary thymic epithelial cell (cTEC and mTEC) lineages are essential for inducing T cell lineage commitment, T cell positive selection and the establishment...

... system allows for such targeted mutagenesis, and we therefore tested it in combination with a piggyBac transposase lineage labeling system to track the development of neocortical neural progenitors with targeted mutations in genes linked to neurodevelopmental disruptions and tumor formation. We show...

... pluripotent stem cells and germ cells to adult stem cells of the lung, liver, muscle, bone and many more. In addition to the stem cell niche, the meeting focused on a number of cutting edge topics such as cell fate transitions and lineage reprogramming, as well as stem cells in ageing and disease, including...

... no competing financial interests. © 2013. Published by The Company of Biologists Ltd 2013 Lineage Neuronal circuits Neocortex The mammalian cerebral cortex is composed of the archicortex (hippocampal region), the paleocortex (olfactory cortex) and the neocortex, with the last being...

... to combinatorial expression of spectrally distinct fluorescent proteins (RFP, YFP and CFP) in neighboring cells, creating a ‘Brainbow’ of colors. The random combination of fluorescent proteins provides a way to distinguish adjacent cells, visualize cellular interactions and perform lineage analyses. Here, we...

...Francisco L. A. F. Gomes; Gen Zhang; Felix Carbonell; José A. Correa; William A. Harris; Benjamin D. Simons; Michel Cayouette In vivo cell lineage-tracing studies in the vertebrate retina have revealed that the sizes and cellular compositions of retinal clones are highly variable. It has been...

... control of neuronal numbers is achieved during neural development is largely unclear. Specifically, the role of programmed cell death in control of cell numbers has not been studied in the central brain neuroblast lineages. Here, we focus on four postembryonic neuroblast lineages in the central brain...

... a stereotyped sequence of neuronal and glial progeny. Hunchback and Kruppel specify early temporal identity in two posterior neuroblast lineages (NB7-1 and NB7-3), whereas Pdm and Castor specify late neuronal identity in the NB7-1 lineage. Because Pdm and Castor have only been assayed in one lineage...

... facilitated our understanding of olfaction; however, many other AL neurons remain unidentified. Because neuron types are mostly specified by lineage and temporal origins, we use the MARCM techniques with a set of enhancer-trap GAL4 lines to perform systematical lineage analysis to characterize neuron...

...Rushu Luo; Juan Gao; Bernhard Wehrle-Haller; Paul D. Henion Clonal and lineage analyses have demonstrated that although some neural crest cells have the ability to generate multiple cell types and display self-renewal ability, other crest cells generate a single or limited repertoire of cell types...

...Xi Xi Jia; Melody V. S. Siegler The median neuroblast lineage of grasshopper has provided a model for the development of differing neuronal types within the insect central nervous system. According to the prevailing model, neurons of different types are produced in sequence. Contrary to this, we...

...Sharon Kessler; Sumer Seiki; Neelima Sinha Differentiation of plant cells is regulated by position-dependent mechanisms rather than lineage. The maize Extra cell layers1 ( Xcl1 ) mutation causes oblique, periclinal divisions to occur in the protoderm layer. These protodermal periclinal divisions...

... mechanisms of this requirement are poorly understood. We have performed lineage tracing in combination with molecular marker studies to follow morphogenetic movements and cell fates before and during gastrulation in embryos mutant for the homeobox gene Otx2 . Our results show, first, that Otx2...

... of such mutations requires a detailed description of the polarity of the asymmetric divisions in the sensory organ lineages. We describe the pattern of cell divisions generating the vp1-vp4a mono-innervated external sense (es) organs. Each sensory organ precursor (SOP) cell follows a series of four asymmetric cell...

... normally generated on or after E36. This finding is in accordance with lineage studies suggesting that E36 progenitors will normally produce not only layer 4 neurons but also the progenitor cells that populate layer 2/3 ( Luskin et al., 1988 ; Price and Thurlow, 1988 ; Walsh and Cepko, 1988 ; Reid et al...

...Aloisia Schmid; Akira Chiba; Chris Q. Doe An experimental analysis of neurogenesis requires a detailed understanding of wild-type neural development. Recent DiI cell lineage studies have begun to elucidate the family of neurons and glia produced by each Drosophila embryonic neural precursor...

..., the founders of a dorsal body wall muscle (DA1). In addition to zfh-1 , mesodermal eve itself appears to be needed for correct EPC differentiation, possibly as a direct target of zfh-1 . Epistasis experiments show that zfh-1 specifies EPC development independently of numb , the lineage gene that controls DA1...