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Keywords: limb regeneration
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Journal Articles
Journal: Development
Development (2022) 149 (5): dev200282.
Published: 11 March 2022
... in the proximal-distal axis of limbs. However, there is no direct genetic evidence that Hox genes are essential for limb development in non-mammalian tetrapods or for limb regeneration. Here, we produced single to quadruple Hox13 paralog mutants using the CRISPR/Cas9 system in newts ( Pleurodeles waltl ), which...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (11): dev199158.
Published: 9 June 2021
...Can Aztekin; Tom W. Hiscock; John Gurdon; Jerome Jullien; John Marioni; Benjamin David Simons ABSTRACT Absence of a specialized wound epidermis is hypothesized to block limb regeneration in higher vertebrates. However, the factors preventing its formation in regeneration-incompetent animals...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (14): dev170829.
Published: 31 July 2020
... BMP signaling is blocked, but ectopic injection of either human or axolotl protein did not rescue the defects. By administering LDN193189 treatments at different time points during regeneration, we show clearly that limb regeneration progresses in a proximal to distal fashion. This demonstrates...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (1): dev169128.
Published: 2 January 2019
...Stephanie L. Tsai; Clara Baselga-Garriga; Douglas A. Melton ABSTRACT Blastema formation, a hallmark of limb regeneration, requires proliferation and migration of progenitors to the amputation plane. Although blastema formation has been well described, the transcriptional programs that drive...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (1989) 107 (Supplement): 109–119.
Published: 1 April 1989
... morphogenetically in the developing nervous system. Key words: retinoic acid-binding protein, retinol-binding protein, retinoic acid, retinol, chick limb bud, chick embryo, pattern formation, axolotl, limb regeneration, neural tube, sensory nerves, ventral floor plate, nervous system. Introduction Vitamin A has...
Journal Articles
Journal: Development
Development (1986) 93 (1): 51–72.
Published: 1 April 1986
.... To explore further the formation of these unusual muscle patterns, Maden & Mustafa (1984), using the triploid cell marker in axolotls, analysed the cellular contribution to supernumerary limbs, Key words: limb regeneration, pattern discontinuities, cellular contribution, intercalation, axolotl. 52 K. MUNEOKA...
Journal Articles
Journal: Development
Development (1986) 91 (1): 19–34.
Published: 1 February 1986
...S. R. Scadding; M. Maden The objective of this investigation was to compare the effect of vitamin A on limb development and limb regeneration in the same animal, at the same time, thus eliminating the possibility that species differences or different rates of uptake between animals would influence...
Journal Articles
Journal: Development
Development (1985) 90 (1): 1–12.
Published: 1 December 1985
... that the limb regeneration blastema of urodeles is composed of cells of local stump origin. Recent advances for using the triploid cell marker in the axolotl, Ambystoma mexicanum, now make it possible to begin to analyse cellular contribution to the regeneration process in greater detail (Muneoka, Wise, Fox...