...Hasan Asfour; Estelle Hirsinger; Raquel Rouco; Faouzi Zarrouki; Shinichiro Hayashi; Sandra Swist; Thomas Braun; Ketan Patel; Frédéric Relaix; Guillaume Andrey; Sigmar Stricker; Delphine Duprez; Amalia Stantzou; Helge Amthor ABSTRACT The mechanism of pattern formation during limb muscle development...

..., but differentiated into muscle fibers when they arrived in the limb bud. In contrast, cells overexpressing FGFR1 migrated into the limb muscle mass but remained as undifferentiated myoblasts. Cells infected with the ΔFGFR1-producing virus failed to migrate to the somato- pleure but were capable of differentiating...

... expression levels delineates the medial and lateral halves of the dermomyotome, which contain precursors of axial (back) muscle and limb muscle, respectively. Pax-3 expression is then repressed as dermomyotome-derived cells activate MDFs. Quail-chick chimera and ablation experiments confirmed...

...Eva Bober; Thomas Franz; Hans-Henning Arnold; Peter Gruss; Patrick Tremblay ABSTRACT Limb muscles in vertebrates originate from dermomyotomal cells, which during early development migrate from the ventrolateral region of somites into the limb buds. These progenitor cells do not express any muscle...

... in the medial half of the newly formed somite. On the other hand, virtually all of the cells residing in the lateral half of the newly formed somite are destined to leave the somite proper and populate the limb muscle and, probably, other somite-derived mesenchymal structures in the limb and ventral body wall...

... interspecific (chick/quail) and intraspecific (chick/chick) chimaeric studies, involving the heterotopic transplantation of unsegmented somitic mesoderm, indicate that the ability of premyogenic cells to form specific limb muscles is determined by positional cues operative in the host embryo. To determine...