.... WNT7A and RECK have been shown previously to play a role in limb development, but the mechanism of RECK action in this context is unknown. The roles of WNT7B and GPR124 in limb development have not been investigated. Using combinations of conventional and/or conditional loss-of-function alleles...

...Takashi Takeuchi; Haruka Matsubara; Fumina Minamitani; Yukio Satoh; Sayo Tozawa; Tomoki Moriyama; Kohei Maruyama; Ken-ichi T. Suzuki; Shuji Shigenobu; Takeshi Inoue; Koji Tamura; Kiyokazu Agata; Toshinori Hayashi ABSTRACT The 5′Hox genes play crucial roles in limb development and specify regions...

... these, 65 are SMAD4 target genes and 37 are essential for limb development ( Tissières et al., 2020 ). These results indicate that SMAD4 and SHH co-regulate GRNs with essential functions in early mouse limb buds. Strikingly, the majority of the shared DEGs are regulated in a discordant manner (79 genes...

... , Y. , Calof , A. L. , Lander , A. D. and Schilling , T. F. ( 2014 ). Nipbl and mediator cooperatively regulate gene expression to control limb development . PLoS Genet.   10 , e1004671 . 10.1371/journal.pgen.1004671 Pal , R. , Ramdzan , Z. M. , Kaur , S...

... syndrome, and Lowry-Wood syndrome. Similarly, primordial dwarfism in domesticated animals is linked to positive selection in minor spliceosome components. Despite being vital for limb development and size regulation, its role remains unexplored. Here, we disrupt minor spliceosome function in the developing...

... have limited predictive value for identifying enhancer mutations with strong loss-of-function phenotypes during development. Enhancer-promoter interactions Genomics Limb development Enhancer loss-of-function mutations National Institute of General Medical Sciences 10.13039/100000057...

... signatures regulated during limb development and provides a data resource for future studies of connective tissue formation. Chicken model Limb development Connective tissue differentiation Extracellular matrix Signalling pathways Transcription factors Transcriptional regulatory network...

... Highlighted Article: The mutation in the PMA mouse model of human clubfoot was mapped and a candidate gene, Limk1 , identified that was shown to cause sciatic nerve and limb abnormalities when overexpressed. Limk1 Axon guidance Clubfoot Limb development Chicken Experiments were performed...

... in other processes, such as limb development, is unknown. In this study, we generated limb mesenchymal cell-specific Uhrf1 knockout mice ( Uhrf1 Δ Limb/ Δ Limb , cKO). The cKO mice had short and deformed limbs caused by growth plate irregularities. Given the ability of Uhrf1 to regulate cell...

...-proximal limb elements in mice. Hand1 bHLH Dimerization Limb development Transcription Mouse The vertebrate limb is an evolutionarily dynamic structure that has adapted broadly to fit the intended functional role, be it running, climbing, flying or swimming. As a consequence...

...Patricia Saiz-Lopez; Kavitha Chinnaiya; Matthew Towers; Maria A. Ros ABSTRACT An intrinsic timing mechanism specifies the positional values of the zeugopod (i.e. radius/ulna) and then autopod (i.e. wrist/digits) segments during limb development. Here, we have addressed whether this timing mechanism...

... SOX9 Chondrogenesis Limb development Progenitor cells National Institutes of Health 10.13039/100000002 R01HD073151 Cancer Prevention Research Institute of Texas RP120343 Differentiating cartilage elements are specified from a highly proliferative mesodermal...

... by The Company of Biologists Ltd 2016 Summary: Inhibiting fibroblast migration during regeneration in axolotl reveals the importance of fibroblasts for blastema-based limb regeneration but not non-blastemal skin regrowth. Beryllium Regeneration Wound healing Limb development Ambystoma...

... of the mouse limb . Development   132 , 797 - 803 . 10.1242/dev.01613 Sun , M. , Ma , F. , Zeng , X. , Liu , Q. , Zhao , X.-L. , Wu , F.-X. , Wu , G.-P. , Zhang , Z.-F. , Gu , B. , Zhao , Y.-F. , et al. ( 2008 ). Triphalangeal thumb-polysyndactyly syndrome...

.... Limb development is a well-studied topic in vertebrate organogenesis. Nevertheless, there is still little understanding of tissue-level deformation relative to molecular and cellular dynamics. This is mainly because live recording of detailed cell behaviors in whole tissues is technically difficult...

...Idit Eshkar-Oren; Sharon Krief; Napoleone Ferrara; Alison M. Elliott; Elazar Zelzer Blood vessels serve as key regulators of organogenesis by providing oxygen, nutrients and molecular signals. During limb development, programmed cell death (PCD) contributes to separation of the digits...

... 3 3 2014 © 2014. Published by The Company of Biologists Ltd 2014 Enhancer Gli Gremlin Limb development Silencer Sonic Hedgehog Mouse The Hedgehog (Hh) pathway is one of the primary signaling mechanisms underlying developmental patterning in organisms ranging from...

... ZRS Limb development Mouse Multi-species conserved non-coding elements occur in the vertebrate genome and are clustered often within large gene deserts in the vicinity of developmentally regulated genes ( Boffelli et al., 2004 ; Woolfe et al., 2005 ). Many act as cis -regulators...

... 2013 22 8 2013 © 2013. Published by The Company of Biologists Ltd 2013 Hox genes Limb development Stromal cells Musculoskeletal integration Connective tissue Mouse The vertebrate limb provides a powerful system for the study of tissue patterning...

...Rushikesh Sheth; Damien Grégoire; Annie Dumouchel; Martina Scotti; Jessica My Trang Pham; Stephen Nemec; Maria Félix Bastida; Marian A. Ros; Marie Kmita Limb development relies on an exquisite coordination between growth and patterning, but the underlying mechanisms remain elusive. Anterior...