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Keywords: limb bud
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Journal Articles
Journal: Development
Development (2012) 139 (22): 4250–4260.
Published: 15 November 2012
...Jean-Denis Bénazet; Emanuele Pignatti; Ashleigh Nugent; Erkan Unal; Frédéric Laurent; Rolf Zeller SMAD4 is an essential mediator of canonical TGFβ/BMP signal transduction and we inactivated Smad4 in mouse limb buds from early stages onward to study its functions in the mesenchyme. While this Smad4...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (17): 3759–3767.
Published: 1 September 2011
...Laurie A. Wyngaarden; Paul Delgado-Olguin; I-hsin Su; Benoit G. Bruneau; Sevan Hopyan Specification and determination (commitment) of positional identities precedes overt pattern formation during development. In the limb bud, it is clear that the anteroposterior axis is specified at a very early...
Journal Articles
Journal: Development
Development (2010) 137 (15): 2551–2558.
Published: 1 August 2010
...Laurie A. Wyngaarden; Kevin M. Vogeli; Brian G. Ciruna; Mathew Wells; Anna-Katerina Hadjantonakis; Sevan Hopyan The vertebrate limb bud arises from lateral plate mesoderm and its overlying ectoderm. Despite progress regarding the genetic requirements for limb development, morphogenetic mechanisms...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (7): 1397–1406.
Published: 1 April 2007
...Kosei Sato; Yutaka Koizumi; Masanori Takahashi; Atsushi Kuroiwa; Koji Tamura Pattern formation along the proximal-distal (PD) axis in the developing limb bud serves as a good model for learning how cell fate and regionalization of domains, which are essential processes in morphogenesis during...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (5): 909–919.
Published: 1 March 2007
... in differentiating embryonic stem (ES) cells and in the tailbud of the embryo. However, looping out and decondensation are not simply two different manifestations of the same underlying change in chromatin structure. We show that, in the limb bud of the embryonic day 9.5 embryo,where Hoxd is also activated...
Journal Articles
Journal: Development
Development (2005) 132 (10): 2489–2499.
Published: 15 May 2005
.... 2005 Sirenomelia Twisted gastrulation (Twsg1) Bmp Bmp4 Morpholino Limb bud TGFβ Chordin Dorsoventral patterning Mouse Xenopus Sirenomelia is a human developmental malformation that has been a source of enduring interest. The abnormal fetuses are characterized by the fusion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (14): 3401–3410.
Published: 15 July 2004
...Odyssé Michos; Lia Panman; Kristina Vintersten; Konstantin Beier; Rolf Zeller; Aimée Zuniga Epithelial-mesenchymal feedback signaling is the key to diverse organogenetic processes such as limb bud development and branching morphogenesis in kidney and lung rudiments. This study establishes...
Journal Articles
Journal: Development
Development (2002) 129 (1): 211–220.
Published: 1 January 2002
... in the grafted limb bud (white arrowhead) as well as in the host wing bud. (C) Another example of a wing graft in the leg-level median region. Tbx4 is expressed in the host leg bud but is not detected in the grafted limb bud (arrowhead). (D) Expression of Tbx5/Tbx4 in a wing graft at the leg level, analyzed...
Journal Articles
Journal: Development
Development (1986) 97 (1): 239–250.
Published: 1 September 1986
...M. Maden; D. Summerbell The application of retinoic acid (RA) to the developing chick limb bud causes 6-digit double posterior limbs to form instead of the normal 3-digit limb. As an attempt to begin a molecular analysis of this phenomenon we have identified and characterized a soluble cytoplasmic...
Journal Articles
Journal: Development
Development (1986) 94 (1): 257–265.
Published: 1 June 1986
...Amata Hornbruch; Lewis Wolpert Hensen's node from stage 4 to stage 10 shows polarizing activity when grafted to the anterior margin of the chick limb bud. It can specify additional digits though its action is somewhat attenuated when compared with the effect of a grafted polarizing region. At stage...
Journal Articles
Journal: Development
Development (1985) 86 (1): 89–108.
Published: 1 April 1985
... & Saunders, 1983). Apical ectodermal ridge (AER) is the name of a particular structure of ectodermal cells which increase in thickness and become pseudostratified on the tip of the limb bud. Generally, cell and tissue interactions may be mediated by chemical messengers (McMahon, 1974). Among the chemical...