..., and for subsequent large-scale generation of clinically relevant, light-focusing micro-lenses. Lens development Stem cell Organoid Focus Cataract Vx-770 Medical Advances Without Animals Trust 10.13039/501100001220 Rebecca L. Cooper Medical Research Foundation 10.13039/501100001061...

...([email protected]) 2 9 2009 © 2009. 2009 Cdc42 IRSp53 (Baiap2) Eye development Filopodia Lens development Morphogenesis Mouse A fundamental process in determining the shape of organs is cellular sheet folding and invagination (Lecuit and Lenne, 2007) as exemplified...

... (e-mail: [email protected]) 1 7 2008 © 2008. 2008 Cited2 Hyaloid vasculature Lens development Mouse Cited2 [Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2] is one of the founding members of a family of transcriptional modulators...

... enhancer-deficient embryos exhibit distinctive defects at every stage of lens development. These include a thinner lens placode, reduced placodal cell proliferation, and a small lens pit and lens vesicle. In addition, the lens vesicle fails to separate from the surface ectoderm and the maturing lens...

... inhibitors of Fgfr kinase activity, we showed that both the transcription level and protein expression of Pax6, a transcription factor critical for lens development, was diminished in the presumptive lens ectoderm; (2) transgenic mice (designated Tfr7) that expressed a dominant-negative Fgf receptor...

... in determining lens polarity and growth patterns is suggested by the anterior-posterior differences in the bio-availability of FGF in the ocular media and capsule. * Author for correspondence 08 02 1993 © 1993 by Company of Biologists 1993 fibroblast growth factor lens development...

... or not the Elo gene regulates cell proliferation during lens development. The lens fiber cells were morphologically abnormal in day 13 embryonic Elo lens. However, there were no significant differences in morphology or cell proliferation between normal and Elo lens epithelium until day 14 of gestation. After day...

... determination lens development optic vesicle Xenopus laevis The first experimental demonstration that the formation of one embryonic tissue depends on its interaction with an adjacent tissue was performed by Spemann (1901) , who showed that lens formation is dependent on an interaction...