...://www.biologists.com/user-licence-1-1/ Summary: Single and double mutants generated in the zebrafish nodal , lefty1 and cerl2/dand5 genes reveal that the mechanisms of left-right patterning are highly conserved between zebrafish and mouse. Left-right patterning Nodal Southpaw Cerl2 Dand5 Lefty...

... southpaw Zebrafish Bmp Left-right asymmetry Midline barrier lefty © 2011. 12 8 2011 Competing interests statement The authors declare no competing financial interests. * Author for correspondence ( [email protected] ) To analyze Bmp4 in L/R...

... interests. © 2011. Wnt TGFβ Nodal BMP Dorsal-ventral axis Anterior-posterior axis Lefty Chordin Six3 FoxQ2 Ciliary band Apical organ Ectoderm patterning Neural development Neural patterning Rapid progress has been made in the last five years...

... (here, Xnr1 or Nodal1 in Xenopus ) and Lefty interact in a cross-regulatory relationship in mesendoderm induction, and are the conserved instructors of left-right (LR) asymmetry in early somitogenesis stage embryos. By expressing Xnr1 and Lefty proproteins that produce mature functional epitope-tagged...

... downregulate goosecoid on the dorsal side, but in contrast to earlier reports that nodal and lefty are upstream of pitx2 , ectopic pitx2c in other regions induces cyclops, lefty2 and goosecoid expression. Asymmetric isoform expression occurs in non-overlapping domains, with pitx2c in left dorsal diencephalon...

...Abby M. S. Cheng; Bernard Thisse; Christine Thisse; Christopher V. E. Wright ABSTRACT In mouse, lefty genes play critical roles in the left-right (L-R) axis determination pathway. Here, we characterize the Xenopus lefty-related factor antivin (Xatv). Xatv expression is first observed...

... demonstrates that a balance of lefty and cyclops signaling is required for normal mesendoderm patterning and goosecoid, no tail and pitx2 expression. In late somite-stage embryos, lft1 and lft2 are expressed asymmetrically in the left diencephalon and left lateral plate respectively, suggesting an additional...

...Claire Chazaud; Pierre Chambon; Pascal Dollé ABSTRACT Determination of the left-right position (situs) of visceral organs involves lefty, nodal and Pitx2 genes that are specifically expressed on the left side of the embryo. We demonstrate that the expression of these genes is prevented...