... Medical and Life Sciences Research Fund http://dx.doi.org/10.13039/100012335 Warwick Medical School http://dx.doi.org/10.13039/501100004443 Left-right asymmetry FurinA RNA element Ybx1 3′UTR Translational control CRISPR/Cas editing Nodal signalling Heart development Cardiac...

... that the original work is properly attributed. Summary: Doctor No, a Drosophila AWP1 ortholog, activates JAK/STAT signaling via Dome receptor endocytosis in a crucial step for left–right asymmetry in the developing gut. Left–right asymmetry JAK/STAT signaling Asymmetric development Endocytic...

... , 1084 - 1097 . 10.1016/j.cell.2012.04.021 Nonaka , S. , Tanaka , Y. , Okada , Y. , Takeda , S. , Harada , A. , Kanai , Y. , Kido , M. and Hirokawa , N. ( 1998 ). Randomization of left-right asymmetry due to loss of nodal cilia generating leftward flow...

... of Biologists Ltd 2021 Summary: Single-minded 2 , homolog of a gene required for gut looping in Drosophila , acts downstream of Pitx2 to regulate asymmetric stomach curvature in vertebrates. Left-right asymmetry Stomach Morphogenesis Pitx2 Sim2 Down syndrome Frog Eunice Kennedy...

... Hum. Dev.   90 , 921 - 925 . 10.1016/j.earlhumdev.2014.09.017 Almirantis , Y. ( 1995 ). Left-right asymmetry in vertebrates . BioEssays   17 , 79 - 83 . 10.1002/bies.950170114 Andrew , A. ( 1961 ). A simple teaching model illustrating the rotation of the gut . J. Med...

... are the two key regulators for the establishment of amphioxus left-right asymmetry, likely representing an evolutionarily conserved mechanism in deuterostomes. Amphioxus Left-right asymmetry Embryonic development Hh signalling Cilium National Natural Science Foundation of China 10.13039...

.... We also uncovered evidence for defects in left-right asymmetry within atrial cardiomyocyte populations. Furthermore, we were able to detail defects in cardiac outflow tract and valve development associated with Pitx2 . Our findings offer insight into Pitx2 function and provide a compilation of gene...

.... and Yost , H. J. ( 2004 ). The T box transcription factor no tail in ciliated cells controls zebrafish left-right asymmetry . Curr. Biol.   14 , 685 - 690 . 10.1016/j.cub.2004.04.002 Amaya , E. , Musci , T. J. and Kirschner , M. W. ( 1991 ). Expression of a dominant negative...

... defects, are mainly associated with an early dysfunction of the left-right organiser, which also impacts the formation of other visceral organs. As studies in animal models indicate that left-right asymmetry of the heart is a multi-step process, it is possible that genetic variations in later determinants...

... in amphioxus causes loss of Cer expression and bilateral expression of Nodal , Pitx and Lefty , revealing a novel role in LR patterning in this ancient chordate. Hedgehog Cerberus Left-right asymmetry Embryonic development Amphioxus National Natural Science Foundation of China...

... interaction with Nup98, in the Xenopus left-right organizer. Nek2 Cilia Congenital heart disease Left-right asymmetry Nucleoporin The vertebrate left-right (LR) axis is the last body axis to be established, after the anteroposterior and dorsoventral axes. Thus, LR asymmetry presents...

... License ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Cilia Evolution Left-right asymmetry Left-right organizer Leftward flow Symmetry is a guiding...

... summarize here, leaders in the field gathered at the symposium to discuss recent advances in understanding how left-right asymmetry is generated and utilized across the animal kingdom. * Authors for correspondence ( [email protected] ; [email protected] ) Competing interests The authors...

... giant larvae 2 ( lgl2 ) is expressed prominently in ciliated organs. Lgl proteins are involved in establishing cell polarity and have been implicated in vesicle trafficking. Here, we identified a role for Lgl2 in development of ciliated epithelia in Kupffer’s vesicle, which directs left-right asymmetry...

... by The Company of Biologists Ltd 2012 Autotaxin Lysophosphatidic acid Calcium Left-right asymmetry Zebrafish Left-right (L-R) patterning is a fundamental process in vertebrate embryogenesis. Establishment of L-R asymmetry in vertebrates has been studied extensively and two embryonic structures...

... Cilia Left-right asymmetry The establishment of left-right (LR) asymmetry during early embryogenesis is crucial for the correct positioning and morphogenesis of internal organs. This process involves a number of intricately regulated developmental mechanisms, some of which appear...

... interests. 22 4 2012 © 2012. Left-right asymmetry Endoderm Gap junction Sox17 Nodal Establishing a three-dimensional axis, with anteroposterior, dorsoventral and left-right (LR) coordinates, is a critical step in embryogenesis. LR axis determination provides...

[email protected] ) Competing interests statement The authors declare no competing financial interests. 19 3 2012 © 2012. Zebrafish Left-right asymmetry Wnt β-Catenin Nodal Regardless of symmetric external appearance, vertebrates have left-right (LR) asymmetric...

... no competing financial interests. 6 3 2012 © 2012. DE-Cadherin Left-right asymmetry Myo31DF Myosin IC Myosin ID Shotgun Drosophila Myo61F L/R patterning is required for the functional organization of the body plan and the L/R asymmetric development...

...Kazuhiko Nishide; Michio Mugitani; Gaku Kumano; Hiroki Nishida Tadpole larvae of the ascidian Halocynthia roretzi show morphological left-right asymmetry. The tail invariably bends towards the left side within the vitelline membrane. The structure of the larval brain is remarkably asymmetric. nodal...