... ). Similar to mammals, zebrafish vSMC derive from the lateral plate mesoderm and, more precisely, from a population of cells adjacent to the sclerotome region ( Kelley et al., 2019 ; Santoro et al., 2009 ; Stratman et al., 2017 ). The advantages of the zebrafish system for live imaging have also shown...

...Karin D. Prummel; Susan Nieuwenhuize; Christian Mosimann ABSTRACT The lateral plate mesoderm (LPM) forms the progenitor cells that constitute the heart and cardiovascular system, blood, kidneys, smooth muscle lineage and limb skeleton in the developing vertebrate embryo. Despite this central role...

... homeostasis during development. Despite these crucial roles, the origin of iSMCs and the mechanisms responsible for their differentiation and function remain largely unknown in vertebrates. Here, we demonstrate that iSMCs arise from the lateral plate mesoderm (LPM) in a stepwise process. Combining...

... describe a Tbx5a-dependent cell convergence pattern that is both asymmetric and topological within the fin-field lateral plate mesoderm during early fin bud initiation. We further demonstrate that a mesodermal Fgf24 convergence cue controlled by Tbx5a underlies this asymmetric convergent motility. Partial...

..., are expressed in the anterior lateral plate mesoderm (ALPM) and predominantly overlap with vascular progenitors (VPs). Although singular knockdown of Cyp26a1 or Cyp26c1 does not overtly affect cardiovascular development, double Cyp26a1 and Cyp26c1 (referred to here as Cyp26)-deficient embryos have increased...

... environment that facilitate cell behavior and the inherent traits of the cardiomyocytes that control their motility. However, the mechanisms that coordinate extrinsic and intrinsic influences on morphogenesis remain poorly understood. Zebrafish Heart morphogenesis Lateral plate mesoderm Hand2...

...Per Wasteson; Bengt R. Johansson; Tomi Jukkola; Silke Breuer; Levent M. Akyürek; Juha Partanen; Per Lindahl Aortic smooth muscle cells (SMCs) have been proposed to derive from lateral plate mesoderm. It has further been suggested that induction of SMC differentiation is confined to the ventral...

.... One of the genes specifically expressed in the lateral plate mesoderm, and later in its derivative, the visceral mesoderm, is the Fox gene FoxF1. Its function is critical for Xenopus gut development, and embryos injected with FoxF1 morpholino display abnormal gut development. In the absence of FoxF1...

... on the left side ( Collignon et al., 1996 ; Lowe et al., 1996 ). At the same stages, nodal is also expressed in the lateral plate mesoderm (LPM) but only on the left side. Asymmetric expression is evolutionarily conserved, being found in every vertebrate examined ( Collignon et al., 1996 ; Fujinaga et al...

...Deborah Yelon; Baruch Ticho; Marnie E. Halpern; Ilya Ruvinsky; Robert K. Ho; Lee M. Silver; Didier Y. R. Stainier ABSTRACT The precursors of several organs reside within the lateral plate mesoderm of vertebrate embryos. Here, we demonstrate that the zebrafish hands off locus is essential...

... at the level of lateral plate mesoderm, and the base of the allantois. After 23 hours in culture, operated conceptuses were examined histologically for contribution of donor allantoic cells to the conceptus. None of the allantoic regions contributed to paraxial mesoderm when placed into the fetus, but all...

... the lateral plate mesoderm. In this report, we provide evidence that a member of the fibroblast growth factor (FGF) family, FGF10, emanates from the prospective limb mesoderm to serve as an endogenous initiator for limb bud formation. Fgf10 expression in the prospective limb mesenchyme precedes Fgf8...