... and proinflammatory cytokines in response to the accumulation of mitochondrial reactive oxygen species. Induction of STING activity was found to be dependent on the breast tumor suppressor gene single-minded 2 (SIM2). Using mouse models of lactation, we discovered that loss of STING activity results in early...

...Elitsa Ivanova; Cathy Hue-Beauvais; Johan Castille; Johann Laubier; Sandrine Le Guillou; Etienne Aujean; Jerome Lecardonnel; Laura Lebrun; Florence Jaffrezic; Delphine Rousseau-Ralliard; Christine Péchoux; Martine Letheule; Gilles Foucras; Madia Charlier; Fabienne Le Provost ABSTRACT Lactation...

... cells (MECs) isolated on pregnancy day (P)14 and lactation day (L)2 revealed that the majority of differentially expressed microRNA declined precipitously between late pregnancy and lactation. The decline in miR-150, which exhibited the greatest fold-decrease, was verified quantitatively...

.... However, a lactation defect was observed in mammary glands of Tif1g -null mice. We demonstrate that Tif1 γ is essential for the terminal differentiation of alveolar epithelial cells at the end of pregnancy and to ensure lactation. Tif1 γ appears to play a crucial role in the crosstalk between TGFβ...

... the activities of these two antagonistic pathways are orchestrated to initiate lactation has not been well defined. Here, we show that SnoN, a negative regulator of TGF-β signaling, coordinates TGF-β and prolactin signaling to control alveologenesis and lactogenesis. SnoN expression is induced at late pregnancy...

... expression during lactation. Mammary glands from nulliparous mice expressing Sim2s driven by the mouse mammary tumor virus (MMTV) long terminal repeat (LTR) promoter were morphologically indistinguishable from wild-type mice but displayed hallmarks of precocious lactogenic differentiation. These included...

... activity in the breast have remained elusive. Here,we show that mice with Cre-lox mediated deletions of both Erbb4 alleles within the developing mammary gland ( Erbb4 Flox/Flox Wap-Cre ) fail to accumulate lobuloalveoli or successfully engage lactation at parturition owing, in part, to impaired epithelial...

...Tiffany N. Seagroves; Darryl Hadsell; Jim McManaman; Carol Palmer; Debbie Liao; Wayne McNulty; Bryan Welm; Kay-Uwe Wagner; Margaret Neville; Randall S. Johnson During pregnancy the mammary epithelium and its supporting vasculature rapidly expand to prepare for lactation, resulting in dramatic...

... in postnatal growth and lactation. * Present address: Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA (e-mail: [email protected] ) 24 01 1997 © 1997 by Company of Biologists 1997 winged helix gene fork head gene...