... focussed on the tritocerebrum shows that inactivation of vnd results in regionalized axonal patterning defects, which are comparable with the brain phenotype caused by mutation of the Hox gene labial ( lab ). However, in contrast to lab activity in specifying tritocerebral neuronal identity ,vnd...

.... *Author for correspondence (e-mail: [email protected] ) 12 12 2001 © 2002. 2002 Body plan Centipede Chilopoda Lithobius Hox labial proboscipedia Hox3 Deformed Sex combs reduced fushi tarazu Antennapedia Ultrabithorax abdominal-A Abdominal-B...

... by differential Hox gene action, based on differential spatiotemporal expression patterns, protein sequence differences, interactions with co-factors and regulation of specific downstream genes. During embryonic development of the Drosophila brain, the Hox gene labial is required for the regionalized...

... that bind heterodimers of Labial -type Hox and PBC proteins. Normally, multimerized Labial-PBC binding sites are sufficient to trigger a Labial-specific activation response in either Drosophila or mouse embryos. Here we find that the 21 bp sequence element plays an important role in Deformed specificity...

... of Drosophila and mammals. We then carry out a genetic analysis of the labial gene in embryonic brain development. Our analysis shows that loss-of-function mutation and ubiquitous overexpression of labial results in ectopic expression of neighboring regulatory genes. Furthermore, this analysis demonstrates...

...Jens Riese; Gabi Tremml; Mariann Bienz ABSTRACT The Drosophila endoderm is patterned by the signals Decapentaplegic and Wingless secreted from the visceral mesoderm. This induction culminates in a precise pattern of spatially restricted expression of labial , a selector gene with a role in cell...

...Scott Chouinard; Thomas C. Kaufman ABSTRACT The homeotic gene labial (lab) is required for proper development of the embryonic and adult head in Drosophila melanogaster . The lab gene product accumulates in a complex pattern in both embryonic and imaginal tissue. During embryogenesis, lab...

...Robert J. Diederich; Angela M. Pattatucci; Thomas C. Kaufman Prior developmental genetic analyses have shown that labial (lab) and Deformed (Dfd) are homeotic genes that function in the development of the embryonic (larval) and adult head. Using antibody probes to reveal the spatial distribution...

... abd-A represses dpp . One consequence of dpp expression is the induction of labial (lab) in the underlying endoderm cells. In addition, abd-A function is required for the expression of wg in the visceral mesoderm posterior to the dpp- expressing cells. The two growth factor genes therefore...

...), Ultrabithorax (Ubx) , and Antennapedia (Antp) in the visceral mesoderm. The extracellular dpp protein migrates from the visceral mesoderm across the apposing endodermal cell layer in a region of the endoderm that expresses the homeotic gene labial (lab) . Mesodermal expression of dpp is required...