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Keywords: kreisler
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Journal Articles
Journal: Development
Development (2005) 132 (10): 2309–2318.
Published: 15 May 2005
... duct. However, formation of the lateral semicircular canal and its ampulla is usually unaffected. These inner ear phenotypes are remarkably similar to those reported in kreisler mice, which have inner ear defects attributed to defects in the hindbrain. Based on gene expression analyses, we propose...
Journal Articles
Journal: Development
Development (2002) 129 (22): 5279–5287.
Published: 15 November 2002
... also indicate that val normally represses fgf3 expression in r5 and r6, an interpretation further supported by the effects of misexpressing val in wild-type embryos. This is in sharp contrast to the mouse, in which fgf3 is normally expressed in r5 and r6 because of positive regulation by kreisler...
Journal Articles
Journal: Development
Development (2002) 129 (7): 1645–1655.
Published: 1 April 2002
...Giselbert Hauptmann; Heinz-Georg Belting; Uta Wolke; Karen Lunde; Iris Söll; Salim Abdelilah-Seyfried; Victoria Prince; Wolfgang Driever Segmentation of the vertebrate hindbrain leads to the formation of a series of rhombomeres with distinct identities. In mouse, Krox20 and kreisler play important...
Journal Articles
Journal: Development
Development (2002) 129 (6): 1477–1485.
Published: 15 March 2002
... the bZIP transcription factor encoded by the kreisler gene controls this segmentation process. In kreisler mutants, r5 fails to form and this correlates with abnormalities in the neuroanatomical organisation of the hindbrain. Studies of Hox gene regulation suggest that kreisler may regulate the identity...
Journal Articles
Journal: Development
Development (2001) 128 (11): 2031–2038.
Published: 1 June 2001
... of the hindbrain; formation of otocysts, pharyngeal arches and forelimb buds; and in the closure of the primitive gut. The hindbrain of E8.5 Aα/Aγ embryos shows a posterior expansion of rhombomere 3 and 4 (R3 and R4) markers, but fails to express kreisler , a normal marker of R5 and R6. This abnormal hindbrain...
Journal Articles
Journal: Development
Development (2000) 127 (24): 5297–5307.
Published: 15 December 2000
.... Specific combinations of these markers are associated with each migratory phase in r4, r5 and r6. In Krox20 and kreisler mutant mouse embryos, both of which lack r5, fbm neurones migrate dorsally into the anteriorly positioned r6 and adopt an r6-specific expression pattern. In embryos deficient for Ebf1...
Journal Articles
Journal: Development
Development (2000) 127 (5): 933–944.
Published: 1 March 2000
... patterning defects were analyzed in embryos individually mutant for Hoxa1 and Hoxa2 in greater detail and extended to embryos mutant for both genes. From these data a model is proposed to describe how Hoxa1, Hoxa2, Hoxb1, Krox20 ( Egr2 ) and kreisler function together to pattern the early mouse hindbrain...
Journal Articles
Journal: Development
Development (1999) 126 (22): 5051–5059.
Published: 15 November 1999
... in an enlargement of rhombomere 5, which is likely to be responsible for the induction of supernumerary otic vesicles, in a disappearance of the rhombomere 5/6 boundary, and in profound alterations of rhombomere identities. In the mutant hindbrain, the expression domain of kreisler is twice its normal size...
Journal Articles
Journal: Development
Development (1999) 126 (4): 759–769.
Published: 15 February 1999
... that reflects the upregulation of the endogenous gene in these segments. Deletion analysis localized this activity to a 600 bp fragment that was found to contain a single high-affinity binding site for the Maf bZIP protein Krml1, encoded by the kreisler gene. This site is necessary for enhancer activity...
Journal Articles
Journal Articles
Journal: Development
Development (1998) 125 (3): 393–406.
Published: 1 February 1998
..., we investigate the processes of hindbrain segmentation and the acquisition of segmental identity by analyzing the expression of zebrafish hox genes in the hindbrains of normal fish and fish with a loss-of-function mutation in the segmentation gene valentino ( val , the homologue of mouse kreisler...
Journal Articles
Journal: Development
Development (1998) 125 (3): 381–391.
Published: 1 February 1998
... of the mouse segmentation gene kreisler , which encodes a bZip transcription factor. The valentino gene is expressed in a manner consistent with its proposed role in subdividing rhombomeres 5 and 6 from their common precursor ‘proto-segment’ in the presumptive hindbrain, a process that we also demonstrate...
Journal Articles
Journal: Development
Development (1994) 120 (8): 2199–2211.
Published: 1 August 1994
...Ian J. McKay; Ian Muchamore; Robb Krumlauf; Malcolm Maden; Andrew Lumsden; Julian Lewis ABSTRACT kreisler is a recessive mutation resulting in gross malformation of the inner ear of homozygous mice. The defects in the inner ear are related to abnormalities in the hindbrain of the embryo, adjacent...
Journal Articles
Journal: Development
Development (1993) 119 (2): 319–338.
Published: 1 October 1993
...) and with that of the mice homozygous for the kreisler mutation. * Author for correspondence † Present address: Brookdale Center for Molecular Biology, Mount Sinai Medical Center, 1 Gustave L Levy place, New-York, NY 10029, USA ‡ Present address: Department of Human Anatomy, South Parks Road, Oxford OX1 3QX...