... with each knockout group was then carried out using a two-sided two-sample t -test analysis, with an S0 of 0.1 and a permutation based False Detection Rate (FDR) of 5%, derived from 500 randomisations. Hierarchical clustering was performed in Perseus using average Euclidean distances. All mass spectrometry...

..., leading to biliary cell differentiation. This study was undertaken to analyze how inactivation of the Cebpa gene affects biliary cell differentiation and gene expression of the regulatory genes for that differentiation, including Hnf1b and Hnf6 . In the knockout mouse liver at midgestation stages...

... Laboratories, 126 Lincoln Avenue, Rahway,NJ 07065-0900, USA † These authors contributed equally to this work ‡ Present address: Hôpital Bichat–Claude-Bernard, 46 Rue Henri-Huchard, 75018 Paris, France 14 9 2005 ©2005. 2005 Homologous recombination Knockout Hypertrophic...

... equally to this work 23 5 2005 ©2005. 2005 Foxa1 Knockout Prostate Foxa2 Shh Androgen Mouse Gene inactivation studies in the mouse, combined with organ culture and tissue recombination, have highlighted the essential roles of androgenic signaling and epithelial-stromal...

...., Gustafsson, E., Boot-Handford, R. and Fassler, R. ( 2000 ). Mammalian skeletogenesis and extracellular matrix: what can we learn from knockout mice? Cell Struct. Funct. 25 , 73 -84. Billinghurst, R. C., Dahlberg, L., Ionescu, M., Reiner, A.,Bourne, R., Rorabeck, C., Mitchell, P., Hambor, J...

... basement membrane protein knockouts, these data suggest that laminin is sufficient for basement membrane-like matrices during early development, but at later stages the specific composition of components including collagen IV defines integrity, stability and functionality. No gross abnormalities in organ...

.... To delineate the effects of Math1 on CGC differentiation, we generated and studied primary cultures of CGC progenitors from Math1 / lacZ knockout mice. Rhombic lip precursors appeared properly positioned, expressed CGC-specific markers, and maintained Math1 promoter activity in vivo and in vitro,suggesting...

... GnRH neurons Peripheral nerve Peripheral neuropathy Dysmyelination Homologous recombination Knockout Targeted inactivation Gene targeting COE2 O/E3 Olf/Ebf genes ( Garel et al.,1997 ; Hagman et al.,1993 ; Malgaretti et al.,1997 ; Wang and Reed,1993 ; Wang et al.,1997 ) (reviewed...

.... DNA was prepared from mouse tails as described ( Hogan, 1994 ). Splotch and Msx2 knockout mutants, and Msx2-lacZ transgenes ( Liu et al., 1994 ) genotypes were determined by PCR. Distinguishing the Splotch and wild-type Pax3 alleles required two reactions, one with the UM and CD primers...

... and reciprocal FGF10 signaling from the mesenchyme coordinately regulate epithelial airway branching and organ size during lung embryogenesis. © 2001. 2001 FGF9 FGF FGF receptor Lung Mesenchyme Mouse Knockout Chicken lung graft experiments dating back to 1933 demonstrated that mesenchyme...

...-mail: [email protected] ) 05 04 2001 02 02 2001 © 2001 by Company of Biologists 2001 Ste20 kinase NCK interacting kinase (NIK) misshapen Gastrulation knockout N-terminal JUN kinase (JNK) Mouse Ste20 kinases constitute a large family of protein kinases...

... of telencephalic development. * Author for correspondence (email: [email protected] ) 02 09 200 05 09 2000 © 2000 by Company of Biologists 2000 Mouse Telencephalon Knockout Gsh2 The telencephalon and diencephalon, which comprise the vertebrate forebrain, arise...

[email protected] ) 04 08 2000 © 2000 by Company of Biologists 2000 Knockout Retina Retinal pigmented epithelium Pax Mouse The primordia, which give rise to the complex architecture of the mammalian eye, are regionalized and specified by autonomous as well as inductive cues ( Saha...

... targeting heart defect skeletal defect epithelial-mesenchymal interaction mouse knockout TGFβ2 is a member of the highly conserved TGFβ super gene family that consists of more than thirty ligand proteins (reviewed by Kingsley, 1994 ). Members of this family represent structurally similar, yet...

...-mail: [email protected] ) 18 03 1998 30 01 1998 © 1997 by Company of Biologists 1997 taste buds sensory organ gustatation neurotrophins knockout lingual Taste buds are chemosensory organs consisting of collections of spindle-shaped modified epithelial cells...

..., thereby establishing a nutrient delivery system for the embryo ( Coffin et al., 1991 ; Wilt, 1965 ; Milura and Wilt, 1969 ; Yoder et al., 1994 ; Palis et al., 1995 ). knockout yolk sac primitive endoderm mutagenesis GATA-4 mouse visceral endoderm ...