... are enhanced. Our results also show that ash2 acts as a repressor of the vein L2-organising gene knirps ( kni ), whose expression is upregulated throughout the whole wing imaginal disc in ash2 mutants and mitotic clones. Furthermore, ash2 -mediated inhibition of kni is independent of spalt-major and spalt...

...Paolo Struffi; Maria Corado; Meghana Kulkarni; David N. Arnosti The Drosophila Knirps protein is a short-range transcriptional repressor that locally inhibits activators by recruiting the CtBP co-repressor. Knirps also possesses CtBP-independent repression activity. The functional importance...

...Karen Lunde; Jennifer L. Trimble; Annabel Guichard; Kirsten A. Guss; Ulrich Nauber; Ethan Bier The adjacent knirps ( kni ) and knirps-related ( knrl ) genes encode functionally related zinc finger transcription factors that collaborate to initiate development of the second longitudinal wing vein...

... the transcription factors KNIRPS and KNIRPS RELATED possess multiple and redundant functions during tracheal development. knirps/knirps related activity is necessary to mediate DPP signaling which is required for tracheal cell migration and formation of the dorsal and ventral branches. Ectopic knirps or knirps...

...Karen Lunde; Brian Biehs; Ulrich Nauber; Ethan Bier ABSTRACT The neighboring homologous knirps ( kni ) and knirpsrelated ( knrl ) genes in Drosophila encode transcription factors in the steroid hormone receptor superfamily. During early embryogenesis, kni functions as a gap gene to control...

...David Kosman; Stephen Small ABSTRACT The asymmetric distribution of the gap gene knirps ( kni ) in discrete expression domains is critical for striped patterns of pair-rule gene expression in the Drosophila embryo. To test whether these domains function as sources of morpho-genetic activity...

... the divergence of the vertebrates and Invertebrates. One locus is knirps-related ( knrl ), whose product is closely related to that of the gap segmentation gene knirps ( kni ). knrl is one of the most diverged steroid receptor-like molecules and displays a spatially restricted blastoderm pattern. Copyright ©...