... likely to direct stem cell niche interactions in vivo . In conclusion, the present work supports a crucial role for c-kit and kit ligand/stem cell factor in stimulating the growth, proliferation and nuclear reprogramming of porcine PSCs, and further suggests that porcine PSCs might be the culture...

... of the differentiation marker tyrosinase. Tyrosinase expression can be rescued,however, by the addition of Ednrb wild-type neural tubes. These Ednrb wild-type neural tubes need not be capable of generating melanocytes themselves, but must be capable of providing KIT ligand, the cognate ligand for the tyrosine kinase...

...Youichi Tajima; Hitoshi Onoue; Yukihiko Kitamura; Yoshhake Nishimune ABSTRACT In order to define the role of Kit ligand (KL) growth factor encoded at the mouse steel (SI) locus in spermatogenesis, we have examined its production in Sertoli cells. As a measure KL growth factor bioactivity...