... in distinct regions of the pharyngeal arches illuminates the roles of Edn1 and Jagged-Notch signaling and identifies novel domain-specific genes in craniofacial patterning. Craniofacial Zebrafish Jaw Skeleton Cartilage Bone Cranial neural crest Dorsoventral patterning Endothelin Edn1 Jagged...

... bone regeneration in the lower jaw of adult zebrafish, we show that chondrocytes are crucial for generating thick bone during repair. During jawbone regeneration, we find that chondrocytes co-express genes associated with osteoblast differentiation and produce extensive mineralization, which...

... patterning. Our phenotypic analysis suggests that Boc is required as a positive regulator of Hh signaling in the spinal cord, hypothalamus, pituitary, somites and upper jaw, but that Boc might negatively regulate Hh signals in the lower jaw. This study reveals a role for Boc in ventral CNS cells that receive...

...Juhee Jeong; Xue Li; Robert J. McEvilly; Michael G. Rosenfeld; Thomas Lufkin; John L. R. Rubenstein Dlx transcription factors are implicated in patterning the mammalian jaw,based on their nested expression patterns in the first branchial arch(primordium for jaw) and mutant phenotypes; inactivation...

...Craig T. Miller; Deborah Yelon; Didier Y. R. Stainier; Charles B. Kimmel A conserved endothelin 1 signaling pathway patterns the jaw and other pharyngeal skeletal elements in mice, chicks and zebrafish. In zebrafish, endothelin 1 ( edn1 or sucker ) is required for formation of ventral cartilages...

... marker known for the otic anlage. We provide evidence that foxi1 regulates expression of pax8 , indicating a very early role for this gene in placode formation. In addition, foxi1 is expressed in the developing branchial arches, and jaw formation is disrupted in hearsay mutant embryos. § Author...

...., they have no obvious genetic lesion. Maternal alcoholism or diabetes are found in association with sporadic cases in a pattern that may indicate an interaction between environmental and genetic factors. In most cases, the lower jaw is not affected but sporadic cases do occur with head defects...

...Thomas F. Schilling; Charline Walker; Charles B. Kimmel ABSTRACT During vertebrate development, neural crest cells are thought to pattern many aspects of head organization, including the segmented skeleton and musculature of the jaw and gills. Here we describe mutations at the gene chinless, chn...