...Shannon H. Carroll; Claudio Macias Trevino; Edward B. Li; Kenta Kawasaki; Nikita Myers; Shawn A. Hallett; Nora Alhazmi; Justin Cotney; Russ P. Carstens; Eric C. Liao ABSTRACT Irf6 and Esrp1 are important for palate development across vertebrates. In zebrafish, we found that irf6 regulates...

... transforming growth factor beta (TGFβ) signaling molecules and interferon regulatory factor 6 (Irf6) have been identified as genetic risk factors for cleft palate, little is known about the relationship between TGFβ signaling and IRF6 activity during palate formation. Here, we show that TGFβ signaling...

... for palatal extension, wherein the chondrocytes form a proliferative front, undergo morphological change and intercalate to form the ethmoid plate. Meanwhile, irf6 is required specifically for integration of facial prominences along a V-shaped seam. This work presents a mechanistic analysis of palate...