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Keywords: int-2
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Journal Articles
Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear
Available to Purchase
Journal:
Development
Development (1993) 117 (1): 13–28.
Published: 1 January 1993
...Suzanne L. Mansour; Judy M. Goddard; Mario R. Capecchi ABSTRACT We derived mice that carry a targeted insertion of a neo r gene in the int-2 ( Fgf-3 ) proto-oncogene coding sequences. The mutation was found to be recessive and mice that were homozygous for the insertion did not often survive...
Journal Articles
Mesoderm-inducing properties of INT-2 and kFGF: two oncogene-encoded growth factors related to FGF
Available to Purchase
Journal:
Development
Development (1989) 106 (1): 79–83.
Published: 1 May 1989
... that many proto-oncogenes are differentially expressed during embryonic development and may thus be important embryonic regulatory molecules. We report here that the products of two transforming oncogenes int-2 and hst / ks (now called kfgf) can, with different potencies, induce mesoderm formation...
Journal Articles
Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development
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Journal:
Development
Development (1989) 105 (1): 131–136.
Published: 1 January 1989
...David G. Wilkinson; Sangita Bhatt; Andrew P. Mcmahon The FGF-related proto-oncogene int-2 is implicated in mouse embryogenesis, since it is expressed in specific tissues during gastrulation and neurulation ( Wilkinson et al . 1988 ). Here, we describe the expression of this gene during subsequent...
