... for the development of efficient transposon-mediated insertional mutagenesis in a vertebrate. † Author for correspondence (e-mail: [email protected] ) * Present address: Research Institute for Electronic Science, Hokkaido University, Sapporo 060-0812, Japan 19 10 2007 © 2008. 2008...

... the number of mouse limb mutants is relatively high compared with the number of known genes ( Lyon and Searle, 1989 ). Furthermore, particular aspects of morphogenesis, such as programmed cell death, have yet to be related to any known gene and mutation. insertional mutagenesis limb development...

...Thomas M. Pohl; Marie-Geneviève Mattei; Ulrich Rüther A recessive mutant caused by insertional mutagenesis in transgenic mice has been detected in which the anterior part of the forelimb is disorganized. The morphology of the thumb is always altered and sometimes the adjacent finger has an extra...

... in mice. * To whom correspondence should be addressed © 1990 by Company of Biologists 1990 sex determination Y chromosome Tdy embryonic stem cells chimeras retroviral vectors insertional mutagenesis X:Y pairing The hierarchy of genes involved in sex determination...

.... Such a comparison suggests that the Movl3 allele may not be active in all odontoblasts at all stages. © 1990 by Company of Biologists 1990 odontoblast osteoblast irl(I) collagen gene insertional mutagenesis The Movl3 mouse mutant carries a Moloney leukemia (M-MuLV) provirus inserted...