... epithelium of the mouse cochlea, we investigated the effect of deletion of Ebf1 on inner ear development. We used a Cre driver to delete Ebf1 at the otocyst stage before development of the cochlea. We examined the cochlea at postnatal day (P) 1 and found that the sensory epithelium had doubled in size...

...Marielle O. Beaulieu; Eric D. Thomas; David W. Raible ABSTRACT Death of mechanosensory hair cells in the inner ear is a common cause of auditory and vestibular impairment in mammals, which have a limited ability to regrow these cells after damage. In contrast, non-mammalian vertebrates, including...

... work is properly attributed. Summary: EMX2 expression in the otic prosensory domain marks cell lineages corresponding to hair cells of defined stereociliary bundle polarity and restricted to one side of the mouse utricle or saccule. Hair cell Vestibular Inner ear Planar polarity EMX2...

... ). Math1: an essential gene for the generation of inner ear hair cells . Science 284 , 1837 - 1841 . 10.1126/science.284.5421.1837 Bermingham-McDonogh , O. , Oesterle , E. C. , Stone , J. S. , Hume , C. R. , Huynh , H. M. and Hayashi , T. ( 2006 ). Expression...

...Aitor Bañón; Berta Alsina ABSTRACT Cranial ganglia are aggregates of sensory neurons that mediate distinct types of sensation. The statoacoustic ganglion (SAG) develops into several lobes that are spatially arranged to connect appropriately with hair cells of the inner ear. To investigate...

...Matthew R. Steinhart; Wouter H. van der Valk; Daniel Osorio; Sara A. Serdy; Jingyuan Zhang; Carl Nist-Lund; Jin Kim; Cynthia Moncada-Reid; Liang Sun; Jiyoon Lee; Karl R. Koehler ABSTRACT Inner ear development requires the coordination of cell types from distinct epithelial, mesenchymal and neuronal...

...Yoshitomo Ueda; Takashi Nakamura; Jing Nie; Alexander J. Solivais; John R. Hoffman; Becca J. Daye; Eri Hashino ABSTRACT The inner ear sensory epithelia contain mechanosensitive hair cells and supporting cells. Both cell types arise from SOX2-expressing prosensory cells, but the mechanisms...

... in the ears, kidneys and branchial arches. Here, we have used Six1 -deficient mice, an animal model of the BOR syndrome, to investigate whether dysfunction of senescence underpins the developmental defects associated with SIX1 deficiency. We have focused on the developing inner ear, an organ...

...Amandine Jarysta; Basile Tarchini ABSTRACT Sound transduction occurs in the hair bundle, the apical compartment of sensory hair cells in the inner ear. The hair bundle is formed of actin-based stereocilia aligned in rows of graded heights. It was previously shown that the GNAI-GPSM2 complex is part...

... in the mouse inner ear and also in other organs. * These authors contributed equally to this work ‡ Author for correspondence ( [email protected] ) Handling Editor: François Guillemot Competing interests The authors declare no competing or financial interests. 10 9 2020...

...Evan M. Ratzan; Anne M. Moon; Michael R. Deans ABSTRACT FGF8 signaling plays diverse roles in inner ear development, acting at multiple stages from otic placode induction to cellular differentiation in the organ of Corti. As a secreted morphogen with diverse functions, Fgf8 expression is likely...

... cascades in the inner ear remain largely unknown. Here, we have used Gfi1 cre ;RiboTag mice to evaluate changes to the hair cell translatome in the absence of GFI1. We identify a systematic downregulation of hair cell differentiation genes, concomitant with robust upregulation of neuronal genes in the GFI1...

..., as a candidate for mediating the repressive function of let-7 in HC differentiation and inner ear morphogenesis. Our analysis uncovered an evolutionarily conserved let-7-5p -binding site within the chicken Chd7 gene and its human and murine homologs, and we show that let-7g overexpression in mice limits CHD7...

...Lisa D. Urness; Xiaofen Wang; Chaoying Li; Rolen M. Quadros; Donald W. Harms; Channabasavaiah B. Gurumurthy; Suzanne L. Mansour ABSTRACT Pan-otic CRE drivers enable gene regulation throughout the otic placode lineage, comprising the inner ear epithelium and neurons. However, intersection of extra...

...Simone Schwarzer; Nandini Asokan; Oliver Bludau; Jeongeun Chae; Veronika Kuscha; Jan Kaslin; Stefan Hans ABSTRACT The vertebrate inner ear employs sensory hair cells and neurons to mediate hearing and balance. In mammals, damaged hair cells and neurons are not regenerated. In contrast, hair cells...

... . Recent advances in the field of stem cell biology and organoid culture systems allow the expansion and differentiation of tissue-specific progenitors and pluripotent stem cells in vitro into functional hair cells and otic-like neurons. We discuss how inner ear organoids have been developed and how...

...Aleta R. Steevens; Jenna C. Glatzer; Courtney C. Kellogg; Walter C. Low; Peter A. Santi; Amy E. Kiernan ABSTRACT The transcription factor sex determining region Y-box 2 (SOX2) is required for the formation of hair cells and supporting cells in the inner ear and is a widely used sensory marker...

...Chan Ho Hwang; James Keller; Charles Renner; Sho Ohta; Doris K. Wu ABSTRACT The semicircular canals of the mammalian inner ear are derived from epithelial pouches in which epithelial cells in the central region of each pouch undergo resorption, leaving behind the region at the rim to form a tube...

...://www.biologists.com/user-licence-1-1/ Highlighted Article: Compound homozygous mutants are typically achieved through laborious breeding but the novel CRISPR-stop approach can rapidly generate F0 mice with homozygous zygotic mutations in multiple genes. Inner ear vGlut3 Prestin Otoferlin Base...

... Biol.   165 , 553 - 563 . 10.1083/jcb.200312071 Cohen-Salmon , M. , El-Amraoui , A. , Leibovici , M. and Petit , C. ( 1997 ). Otogelin: a glycoprotein specific to the acellular membranes of the inner ear . Proc. Natl. Acad. Sci. USA   94 , 14450 - 14455 . 10.1073/pnas...