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Keywords: inner ear
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Journal Articles
Journal Articles
Journal: Development
Development (2023) 150 (24): dev201888.
Published: 11 December 2023
... for the generation of inner ear hair cells . Science 284 , 1837 - 1841 . 10.1126/science.284.5421.1837 Bermingham-McDonogh , O. , Oesterle , E. C. , Stone , J. S. , Hume , C. R. , Huynh , H. M. and Hayashi , T. ( 2006 ). Expression of Prox1 during mouse cochlear development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (21): dev201824.
Published: 8 November 2023
...Aitor Bañón; Berta Alsina ABSTRACT Cranial ganglia are aggregates of sensory neurons that mediate distinct types of sensation. The statoacoustic ganglion (SAG) develops into several lobes that are spatially arranged to connect appropriately with hair cells of the inner ear. To investigate...
Includes: Supplementary data
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Human development
Journal: Development
Development (2023) 150 (19): dev201871.
Published: 5 October 2023
...Matthew R. Steinhart; Wouter H. van der Valk; Daniel Osorio; Sara A. Serdy; Jingyuan Zhang; Carl Nist-Lund; Jin Kim; Cynthia Moncada-Reid; Liang Sun; Jiyoon Lee; Karl R. Koehler ABSTRACT Inner ear development requires the coordination of cell types from distinct epithelial, mesenchymal and neuronal...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2023) 150 (9): dev200903.
Published: 3 May 2023
... in the ears, kidneys and branchial arches. Here, we have used Six1 -deficient mice, an animal model of the BOR syndrome, to investigate whether dysfunction of senescence underpins the developmental defects associated with SIX1 deficiency. We have focused on the developing inner ear, an organ...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (14): dev199549.
Published: 21 July 2021
...Amandine Jarysta; Basile Tarchini ABSTRACT Sound transduction occurs in the hair bundle, the apical compartment of sensory hair cells in the inner ear. The hair bundle is formed of actin-based stereocilia aligned in rows of graded heights. It was previously shown that the GNAI-GPSM2 complex is part...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (5): dev196899.
Published: 9 March 2021
... in the mouse inner ear and also in other organs. * These authors contributed equally to this work ‡ Author for correspondence ( [email protected] ) Handling Editor: François Guillemot Competing interests The authors declare no competing or financial interests. 10 9 2020...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (22): dev192849.
Published: 19 November 2020
...Evan M. Ratzan; Anne M. Moon; Michael R. Deans ABSTRACT FGF8 signaling plays diverse roles in inner ear development, acting at multiple stages from otic placode induction to cellular differentiation in the organ of Corti. As a secreted morphogen with diverse functions, Fgf8 expression is likely...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (17): dev186015.
Published: 11 September 2020
... cascades in the inner ear remain largely unknown. Here, we have used Gfi1 cre ;RiboTag mice to evaluate changes to the hair cell translatome in the absence of GFI1. We identify a systematic downregulation of hair cell differentiation genes, concomitant with robust upregulation of neuronal genes in the GFI1...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2020) 147 (13): dev191015.
Published: 8 July 2020
...Lisa D. Urness; Xiaofen Wang; Chaoying Li; Rolen M. Quadros; Donald W. Harms; Channabasavaiah B. Gurumurthy; Suzanne L. Mansour ABSTRACT Pan-otic CRE drivers enable gene regulation throughout the otic placode lineage, comprising the inner ear epithelium and neurons. However, intersection of extra...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (4): dev174748.
Published: 15 February 2019
...Chan Ho Hwang; James Keller; Charles Renner; Sho Ohta; Doris K. Wu ABSTRACT The semicircular canals of the mammalian inner ear are derived from epithelial pouches in which epithelial cells in the central region of each pouch undergo resorption, leaving behind the region at the rim to form a tube...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (20): dev168906.
Published: 17 October 2018
...://www.biologists.com/user-licence-1-1/ Highlighted Article: Compound homozygous mutants are typically achieved through laborious breeding but the novel CRISPR-stop approach can rapidly generate F0 mice with homozygous zygotic mutations in multiple genes. Inner ear vGlut3 Prestin Otoferlin Base...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2017) 144 (20): 3766–3776.
Published: 15 October 2017
... http://www.biologists.com/user-licence-1-1/ Summary: Myosin II plays multiple roles in the cell morphology changes and cellular rearrangements, including radial intercalation, that drive remodeling of the prosensory domain during development of the mouse cochlea. Inner ear Cochlear...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (18): 3349–3360.
Published: 15 September 2017
...Allison M. Nishitani; Sho Ohta; Andrea R. Yung; Tony del Rio; Michael I. Gordon; Victoria E. Abraira; Evelyn C. Avilés; Gary C. Schoenwolf; Donna M. Fekete; Lisa V. Goodrich The vestibular system of the inner ear detects head position using three orthogonally oriented semicircular canals; even...
Includes: Supplementary data