.... Blastocyst Embryo Human Inner cell mass Pluripotency Primate Metazoan life relies on the ability to develop specialised cell types from a single cell. In mammals, preimplantation development entails timely embryonic genome activation, establishment of a pluripotent cell population to form...

...Takuya Azami; Tsuyoshi Waku; Ken Matsumoto; Hyojung Jeon; Masafumi Muratani; Akihiro Kawashima; Jun Yanagisawa; Ichiro Manabe; Ryozo Nagai; Tilo Kunath; Tomonori Nakamura; Kazuki Kurimoto; Mitinori Saitou; Satoru Takahashi; Masatsugu Ema The inner cell mass of the mouse blastocyst gives rise...

...Tomoko Watanabe; John S. Biggins; Neeta Bala Tannan; Shankar Srinivas The formation of trophectoderm (TE) and pluripotent inner cell mass (ICM) is one of the earliest events during mammalian embryogenesis. It is believed that the orientation of division of polarised blastomeres in the 8- and 16...

...Minjung Kang; Anna Piliszek; Jérôme Artus; Anna-Katerina Hadjantonakis The emergence of pluripotent epiblast (EPI) and primitive endoderm (PrE) lineages within the inner cell mass (ICM) of the mouse blastocyst involves initial co-expression of lineage-associated markers followed by mutual exclusion...

... programs in mouse axis and mesoderm formation . Development 130 , 6283 – 6294 . Morris S. A. , Teo R. T. , Li H. , Robson P. , Glover D. M. , Zernicka-Goetz M. ( 2010 ). Origin and formation of the first two distinct cell types of the inner cell mass in the mouse...

...Robert Odell Stephenson; Yojiro Yamanaka; Janet Rossant The first two cell lineages in the mouse, the surface trophectoderm (TE) and inner cell mass (ICM), are morphologically distinguishable by E3.5, with the outer TE forming a polarized epithelial layer enclosing the apolar ICM. We show here...

...Anne K. Voss; Tim Thomas; Petros Petrou; Konstantinos Anastassiadis; Hans Schöler; Peter Gruss ABSTRACT The cells of the inner cell mass constitute the pluripotent cell population of the early embryo. They have the potential to form all of the tissues of the embryo proper and some extra-embryonic...

... in blastocysts represent endocytosed cytocortical sites. See text for details. * Author for correspondence © 1992 by Company of Biologists 1992 mouse preimplantation embryos cell polarity trophectoderm inner cell mass tight junctions ZO-1 cingulin desmosomes Mammalian...

.... Total, trophectoderm (TE) and inner cell mass (ICM) cell numbers were analyzed by differential labelling of the nuclei with polynucleotide specific fluorochromes. The TE nuclei were labelled with one fluorochrome during immunosurgical lysis, before fixing the embryo and labelling both sets of nuclei...

...Jonathan Dyce; Martin George; Harry Goodall; Tom P. Fleming ABSTRACT The extent to which trophectoderm (TE) and inner cell mass (ICM) lineages in the mouse blastocyst remain distinct during the period from the commencement of cavitation up until 48 h later in culture was investigated. Fluorescent...

..., Ontario, M5G 1X5, Canada. 05 08 1986 Copyright © 1986 by Company of Biologists 1986 retinoic acid embryonal carcinoma inner cell mass chimaera mouse Murine embryonal carcinoma (EC) cells, the stem cells of teratocarcinomas derived from embryos or germ cells, can...

...Hester P. M. Pratt ABSTRACT The preimplantation mouse blastocyst consists of two differentiated tissues, the troph-ectoderm (a structurally and functionally polarized epithelium) and the inner cell mass. The divergence of these two cell types can be traced back to a contact dependent polarization...

...Sheila C. Barton; Catharine A. Adams; M. L. Norris; M. A. H. Surani ABSTRACT The developmental potential of inner cell mass (ICM) and trophectoderm (TE) derived from parthenogenetic or biparental gynogenetic embryos was examined in reconstituted blastocysts with normal TE or ICM, respectively...