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Keywords: imprinting
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Journal Articles
Journal: Development
Development (2014) 141 (13): 2702–2711.
Published: 1 July 2014
... acquired from the unfertilised egg during embryogenesis through to the adult drone thorax and loss during spermatogenesis. Intriguingly, this epigenetic reprogramming pattern is the same as that observed for a number of CpGs at imprinted genes in the paternal germ line of mammals ( Ferguson-Smith et al...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2013) 140 (14): 2953–2960.
Published: 15 July 2013
...Thiet Minh Vu; Miyuki Nakamura; Joseph P. Calarco; Daichi Susaki; Pei Qi Lim; Tetsu Kinoshita; Tetsuya Higashiyama; Robert A. Martienssen; Frédéric Berger In mammals and plants, parental genomic imprinting restricts the expression of specific loci to one parental allele. Imprinting in mammals...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (20): 3399–3404.
Published: 15 October 2009
... silences the paternal allele of AtFH5 , restricting its expression to the maternal allele. AtFH5 thus appears to be a new, maternally expressed imprinted gene. We further demonstrate that AtFH5 is responsible for morphological defects caused by the loss of PcG activity in the seed. † Author...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (4): 525–530.
Published: 15 February 2009
... (ncRNA)Kcnq1ot1 regulates epigenetic gene silencing in an imprinted gene cluster in cis over a distance of 400 kb in the mouse embryo, whereas the silenced region extends over 780 kb in the placenta. Gene silencing by the Kcnq1ot1 RNA involves repressive histone modifications, including H3K9me2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (20): 3639–3648.
Published: 15 October 2007
... whether the parent-of-origin-dependent seed abortion caused by lack of the FIS subunit MSI1 is caused by parental imprinting of the MSI1 gene. Our data show that MSI1 is not an imprinted gene and that early paternal MSI1 expression is not sufficient to rescue msi1 mutant seeds. By contrast, expression...
Journal Articles
Journal: Development
Development (2006) 133 (21): 4203–4210.
Published: 1 November 2006
...Annabelle Lewis; Kelly Green; Claire Dawson; Lisa Redrup; Khanh D. Huynh; Jeannie T. Lee; Myriam Hemberger; Wolf Reik The mouse Kcnq1 imprinted domain is located on distal chromosome 7 and contains several imprinted genes that are paternally repressed. Repression of these genes is regulated...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (15): 3727–3735.
Published: 1 August 2004
..., parental-specific imprinting marks are maintained to direct appropriate imprinted gene expression. We previously demonstrated that H19 imprinting could be lost during preimplantation development under certain culture conditions. To define the lability of genomic imprints during this dynamic period...
Journal Articles
Journal Articles
Journal: Development
Development (2000) 127 (21): 4719–4728.
Published: 1 November 2000
...Pantelis Georgiades; Marie Watkins; M. Azim Surani; Anne C. Ferguson-Smith ABSTRACT Genetic analysis has shown that the distal portion of mouse chromosome 12 is imprinted; however, the developmental roles of imprinted genes in this region are not known. We have therefore generated conceptuses...
Journal Articles
Journal: Development
Development (2000) 127 (18): 3923–3930.
Published: 15 September 2000
... mechanism that controls monoallelic gene expression in this domain. * Author for correspondence (email: jfxa1@mole.bio.cam.ac.uk ) 22 08 2000 10 07 2000 © 2000 by Company of Biologists 2000 Igf2 H19 Imprinting Silencer YAC transgene Tongue Skeletal muscle...
Journal Articles
Journal: Development
Development (2000) 127 (14): 3101–3105.
Published: 15 July 2000
... and female cells. In the mouse, the paternally derived X chromosome (X P ) is imprinted and preferentially inactivated in the extraembryonic tissues whereas in the embryonic tissues inactivation is random. To investigate how X P is chosen as an inactivated X chromosome in the extraembryonic cells, we have...
Journal Articles
Journal: Development
Development (1999) 126 (9): 1823–1832.
Published: 1 May 1999
..., erasure of allele-specific methylation associated with imprinted genes, and the re-activation of the X chromosome. The allele-specific differential methylation is involved in regulating the monoallelic expression, and thus the gene dosage, of imprinted genes, which underlies functional differences between...
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Journal Articles
Journal: Development
Development (1995) 121 (12): 4195–4202.
Published: 1 December 1995
...Hiroyuki Sasaki; Anne C. Ferguson-Smith; Alisa S. W. Shum; Sheila C. Barton; M. Azim Surani ABSTRACT The mouse H19 gene is imprinted so that the paternal copy is both methylated and repressed during fetal development. However, the CpG-rich promoter region encompassing the transcription start...
Journal Articles
Journal: Development
Development (1995) 121 (8): 2397–2405.
Published: 1 August 1995
...Yasuyuki Kimura; R. Yanagimachi ABSTRACT Genomic imprinting occurs in both male and female gametes during gametogenesis, but the exact time when imprinting begins and ends is unknown. In the present study we injected nuclei of testicular spermatozoa and round spermatids into mature mouse oocytes...
Journal Articles
Journal: Development
Development (1995) 121 (2): 309–316.
Published: 1 February 1995
... to IGF2 , is monoallelically expressed in all postnatal liver samples analysed. We conclude that the functional imprinting status of IGF2 during postnatal liver development appears to be promoter/enhancer-specific and either partly or completely independent of H19 . 11 11 1994 © 1995...
Journal Articles
Journal: Development
Development (1994) 120 (12): 3529–3536.
Published: 1 December 1994
... of preferential paternal imprinting during days 1 to 9 of in vitro differentiation of ES cells. However, the influence of the Xce locus on the randomness of X-inactivation in embyros seems to operate also in ES cell lines. Our overall conclusion is that the low levels of Xist RNA in female kidney, embryos...