... The authors declare no competing financial interests. 25 6 2013 © 2013. Published by The Company of Biologists Ltd 2013 Imaginal discs Regeneration Growth There are many examples of tissue regeneration in the animal kingdom, ranging from restoration of entire body parts...

... but before the precursors undertake their first division. We suggest that in imaginal discs the unliganded EcR/USP complex acts as a ligand-sensitive `gate' that can be imposed at various points in a developmental pathway, depending on the nature of the cells involved. In this way, the ecdysone signal can...

...Luis Alberto Baena-López; José Carlos Pastor-Pareja; Jaime Resino Imaginal discs contain a population of cells, known as peripodial epithelium, that differ morphologically and genetically from the rest of imaginal cells. The peripodial epithelium has a small contribution to the adult epidermis...

... and the mechanosensory larval organs. We report a novel function of btd and Sp1 :they induce the formation and are required for the growth of the ventral imaginal discs. They act as activators of the headcase ( hdc )and Distal-less ( Dll ) genes, which allocate the cells of the disc primordia. The requirement for btd...

... organs. However, little is known about the molecular pathways that direct cells to stop proliferating when an organ has attained its proper size. We have identified mutations in a novel gene, shar-pei , that is required for proper termination of cell proliferation during Drosophila imaginal disc...

... ability to translocate EXD to the nucleus. Expression of the repressing form of HTH in otherwise wild-type imaginal discs phenocopied hth loss of function. Thus, the repressing form was working as an antimorph, suggesting that normally HTH is required to activate the transcription of downstream target...

... Zinc finger Combgap Imaginal discs Drosophila Secreted polypeptide signaling molecules belonging to several different families regulate the specification of different cell fates in many animal systems. The Hedgehog (HH) family includes some of the most important regulators of pattern...

... , S. S. ( 2000 ). Imaginal discs . In Drosophila Protocols (ed. W. Sullivan , M. Ashburner and R. S. Hawley ), pp. 159 - 173 , Cold Spring Harbor: Cold Spring Harbor Laboratory Press . Brand , M. , Jarman , A. P. , Jan , L. Y. and Jan , Y. N. ( 1993...

.... A. , Holley , B. and Fristrom , J. W. ( 1996 ). A switch in Broad-Complex isoform expression is regulated posttranscriptionally during metamorphosis in Drosophila imaginal discs . Dev. Biol . 177 , 1 – 14 . 10.1006/dbio.1996.0140 Bayer , C. A. , von Kalm , L. and Fristrom...

... to the weak double-time alleles, which appear to affect only the circadian rhythm, discs overgrown alleles, including bona fide null alleles, show strong effects on cell survival and growth control in imaginal discs. Analysis of their phenotypes and molecular lesions suggests that the Discs overgrown protein...

...Julien Royet; Robert Finkelstein ABSTRACT The adult head capsule of Drosophila forms primarily from the eye-antennal imaginal discs. Here, we demonstrate that the head primordium is patterned differently from the discs which give rise to the appendages. We show that the segment polarity genes...

...Julien Royet; Robert Finkelstein ABSTRACT Significant progress has been made towards understanding how pattern formation occurs in the imaginal discs that give rise to the limbs of Drosophila melanogaster . Here, we examine the process of regional specification that occurs in the eye-antennal discs...

... that exd is critically involved in adult morphogenesis, not only in the homeotic function but also in several other developmental processes. 17 04 1995 © 1995 by Company of Biologists 1995 cofactor clonal analysis homeotic genes imaginal discs human pbx genes Drosophila...

.... Clonal analysis in the adult epidermis demonstrates a requirement for Serrate during wing and haltere development. Targeted ectopic expression of Serrate in the imaginal discs using the yeast transcriptional activator Gal4 results in regionally restricted induction of cell proliferation, e. g...

... decapemap/egic (dpp) appears to underlie the pat terning of imaginal discs, the fly equivalent of limb buds. Fig. 6. Overlapping expression domains of Shh (A) and BMP2 (B) in Lhe forelimb of a stage 23 chicken embryo. The limbs or appendages of holometabolous insects develop from...

... positional specificities in imaginal disc tissues . Genes Dev . 3 , 85 – 95 . Agnel , M. , Röder , L. , Griffin-Shea , R. and Vola , C. ( 1992 ). The spatial expression of Drosophilarotund gene reveals that the imaginal discs are organized in domains along the proximal-distal...

... epidermis, the tracheae and the imaginal discs. The average size of pure epidermal clones was five cells. In clones overlapping either other larval tissues or imaginal discs, the average number of epidermal cells was between three and four. The mean relative clone size was 1/5 of the size of the total...

...William J. Brook; Lisa M. Ostafichuk; Jana Piorecky; Mark D. Wilkinson; Daralyn J. Hodgetts; Michael A. Russell When imaginal disc fragments from Drosophila are cultured in adult female hosts, they either duplicate the part of the pattern specified by the fate map, or regenerate to replace...

... laboratories found a unique collagenous peptide that only appears during metamor-phosis of Drosophila melanogaster . The other laboratory previously reported that during 20-hydroxyecdysone-induced eversion of Drosophila imaginal discs a glyco-protein named gp125 arises ( Birr et al., 1990 ). We show...

... patterns imaginal discs Two lines of evidence demonstrate that the cut locus is responsible for specifying the identity of sensory organs in the peripheral nervous system (PNS) of Drosophila (1) embryonic lethal cut mutations result in the antigenic and morphological transformation...