...Haley E. Brown; Brandon P. Weasner; Bonnie M. Weasner; Justin P. Kumar ABSTRACT A fundamental goal of developmental biology is to understand how cell and tissue fates are specified. The imaginal discs of Drosophila are excellent model systems for addressing this paradigm as their fate can...

...-Heininger, 2014 ). As we highlight below, genetic tissue ablation techniques in Drosophila have enabled identification of the regulators and downstream effectors of damage-induced ROS. Damaged imaginal discs release ROS ( Santabárbara-Ruiz et al., 2015 ), which in the eye disc signal to immune cells...

... ). Integrating force-sensing and signaling pathways in a model for the regulation of wing imaginal disc size . Development   139 , 3221 - 3231 . 10.1242/dev.082800 Affolter , M. and Basler , K. ( 2007 ). The Decapentaplegic morphogen gradient: from pattern formation to growth regulation...

... as the genetic manipulation of a subset of these populations. Seven uniquely marked categories of cells are produced by site-directed recombination of three independent cassettes. We have used the TIE-DYE method to estimate the number of founder cells that give rise to the wing-imaginal disc during normal...

... Aos1 Drosophila SUMOylation Uba2 Imaginal disc Animal development is achieved through the coordination of cell growth, cell division and cell death. During the early embryogenesis of Drosophila melanogaster , cells divide rapidly, which is facilitated by maternal deposition of components...

... it completes a novel auto-regulatory loop that modulates BMP activity. * Author for correspondence ( [email protected] ) Competing interests statement 22 11 2010 © 2011. BMP signaling DPP LTL Feedback Imaginal disc Morphogen Throughout multicellular...

... and wings. * Author for correspondence (e-mail: [email protected] ) 4 9 2006 © 2006. 2006 Hox Ultrabithorax decapentaplegic Size control Imaginal disc Drosophila Pattern formation in animals requires the concerted activity of selector genes and signaling...

.... Thus, subcellular localization of Wingless along the apical-basal axis of receiving cells may be instrumental in shaping the Wingless gradient. * Author for correspondence (e-mail: [email protected] ) 3 11 2005 © 2006. 2006 Rab5 Rab7 Rab11 Imaginal disc Polarized endocytosis...

..., nevertheless, some exceptions in genes of the Antennapedia complex( Miller et al., 2001 ). Further, differences in Hox cross-regulation between the embryo and imaginal discs are not unprecedented: the proboscipedia ( pb ) Hox gene is positively regulated by Sex combs reduced in the embryo( Rusch...

...Ansgar Klebes; Anne Sustar; Katherina Kechris; Hao Li; Gerold Schubiger; Thomas B. Kornberg Drosophila imaginal disc cells can switch fates by transdetermining from one determined state to another. We analyzed the expression profiles of cells induced by ectopic Wingless expression to transdetermine...

... Imaginal disc Dpp References Aronson, B. D., Fisher, A. L., Blechman, K., Caudy, M. and Gergen, J. P. ( 1997 ). Groucho-dependent and–independent repression activities of Runt domain proteins. Mol. Cell. Biol. 17 , 5581 -5587. Barolo, S. and Posakony, J. W. ( 2002 ). Three habits...

... are enhanced. Our results also show that ash2 acts as a repressor of the vein L2-organising gene knirps ( kni ), whose expression is upregulated throughout the whole wing imaginal disc in ash2 mutants and mitotic clones. Furthermore, ash2 -mediated inhibition of kni is independent of spalt-major and spalt...

... of expression in imaginal discs from early stages of larval development. In the wing disc, ds is first expressed distally, and later is restricted to the hinge and lateral regions of the notum. Flies homozygous for strong ds hypomorphic alleles display previously uncharacterized phenotypes consisting...

..., development of ecd -null early larval lethal mutants cannot be advanced by Ecd expression targeted to the ring gland or by hormone feeding. Cell-autonomous ecd function, suggested by these experiments, is evidenced by the inability of ecd – clones to survive within developing imaginal discs. Ecd is also...

..., Spain 28 10 2003 © 2004. 2004 Homothorax Distal-less Nubbin Limb development Imaginal disc The progenitors of the adult body regions in Drosophila are set aside in the embryonic ectoderm as discrete groups of cells known as imaginal discs. The disc primordia contain...

...Jun Wu; Stephen M. Cohen The wing imaginal disc comprises the primordia of the adult wing and the dorsal thoracic body wall. During second larval instar, the wing disc is subdivided into distinct domains that correspond to the presumptive wing and body wall. Early activity of the signaling protein...

...Sol Sotillos; Sonsoles Campuzano ABSTRACT We have identified a novel Drosophila gene, DRacGAP , which behaves as a negative regulator of Rho-family GTPases DRac1 and DCdc42. Reduced function of DRacGAP or increased expression of DRac1 in the wing imaginal disc cause similar effects on vein...

...Kaan Certel; Angela Hudson; Sean B. Carroll; Wayne A. Johnson ABSTRACT The Drosophila Vestigial protein has been shown to play an essential role in the regulation of cell proliferation and differentiation within the developing wing imaginal disc. Cell-specific expression of vg is controlled by two...

... at the onset of metamorphosis. * Author for correspondence (e-mail: [email protected] ) 19 04 1999 13 06 1999 © 2000 by Company of Biologists 2000 Drosophila Ecdysone ecdysone receptor ultraspiracle Molting Metamorphosis Imaginal disc During Drosophila...

... rather than sine oculis , as previously believed. optix expression was detected in the eye, wing and haltere imaginal discs. Ectopic expression of optix leads to the formation of ectopic eyes suggesting that optix has important functions in eye development. Although optix and sine oculis belong...