... discuss reprogramming, in vitro gametogenesis, disease modelling and embryo modelling, and we highlight the prospects for leveraging stem cell technologies beyond mammalian species. Since their first derivation in 2006, iPSCs have been recognised for their potential to transform the fields...

... that the original work is properly attributed. Summary: This Review describes how recent technological advances have shed light on the mechanisms underlying human lung development and disease, and outlines the future challenges in this field. Bronchi Alveolar ESC iPSC Progenitor Stem cell Lung...

... stem cells (iPSCs). We find that fNPCs become progressively stiffer en route to pluripotency, and that this stiffening is mirrored by iPSCs becoming more compliant during differentiation towards the neural lineage. Furthermore, we show that the mechanical phenotype of iPSCs is comparable...

... - 708 . 10.1016/j.stem.2016.11.011 Wen , Z. , Christian , K. M. , Song , H. and Ming , G.-l. (2016). Modeling psychiatric disorders with patient-derived iPSCs . Curr. Opin. Neurobiol.   36 , 118 - 127 . 10.1016/j.conb.2015.11.003 Xu , M. , Lee , E. M. , Wen...

...: This Review explores the differences and similarities between the biological processes driving developmental cell differentiation and those mediating cell reprogramming. Reprogramming Development iPSC Stem cell More than 50 years ago, Conrad Waddington published his famous depiction of normal...

... Summary: An approach to assess the chimera-forming ability of PSCs is developed and used to assess the developmental potential of rodent, monkey and human PSCs. Chimera Pluripotency ESC iPSC EpiSC References Bradley , A. , Evans , M. , Kaufman , M. H. and Robertson...