...). (A′-A‴) HCR in situ hybridisation of the same embryo for the hypothalamic markers SHH (A″) and BMP7 (A‴). Note these images are of whole embryos, rather than isolated brains as shown in Fig. 2 . In the forming hypothalamus, SHH and BMP7 are co-expressed. This co-expression forms the biological...

... in the hypothalamus are similarly affected remains unknown. Here, we used single-nucleus RNA sequencing to obtain an unbiased view on the importance of TRα1 for hypothalamic development and cellular diversity. Our data show that defective TRα1 signaling has surprisingly little effect on the development...

... or morphotype-specific pattern variations are apparent. Eye-field transcription factors Telencephalon Hypothalamus Cell identity Astyanax mexicanus Natural variation Centre national de la recherche scientifique http://dx.doi.org/10.13039/501100004794 Fondation pour la...

...Timothy Goodman; Stuart G. Nayar; Shaun Clare; Marta Mikolajczak; Ritva Rice; Suzanne Mansour; Saverio Bellusci; Mohammad K. Hajihosseini ABSTRACT New neurons are generated in the postnatal rodent hypothalamus, with a subset of tanycytes in the third ventricular (3V) wall serving as neural stem...

... of homeostasis. The fenestral protein Plvap regulates the rate of plasma protein entry from the general circulation into the brain parenchyma. Fenestrae PV-1 PV1 Hypothalamus Pituitary Neurohypophysis Neuroendocrine Vascular permeability Blood-brain barrier Zebrafish Homeostasis...

...Travis Fu; Matthew Towers; Marysia A. Placzek Classical descriptions of the hypothalamus divide it into three rostro-caudal domains but little is known about their embryonic origins. To investigate this, we performed targeted fate-mapping, molecular characterisation and cell cycle analyses...

...Yuanyuan Xie; Richard I. Dorsky The hypothalamus, which regulates fundamental aspects of physiological homeostasis and behavior, is a brain region that exhibits highly conserved anatomy across vertebrate species. Its development involves conserved basic mechanisms of induction and patterning...

... that the LIM-homeodomain transcription factor Isl1 is expressed in several subpopulations of developing arcuate neurons and plays crucial roles in their fate specification. Mice with conditional deletion of the Isl1 gene in developing hypothalamus display severe deficits in both feeding and linear growth...

...Robert N. Duncan; Yuanyuan Xie; Adam D. McPherson; Andrew V. Taibi; Joshua L. Bonkowsky; Adam D. Douglass; Richard I. Dorsky The vertebrate hypothalamus contains persistent radial glia that have been proposed to function as neural progenitors. In zebrafish, a high level of postembryonic...

..., human pluripotent stem cells are differentiated into hypothalamic neurons that regulate sleep, feeding behavior and metabolism. Differentiation Hypothalamus Narcolepsy Neuropeptide Pluripotent Stem cell Mouse Human Although it makes up only 0.3% of the adult human brain...

... NPY Hypothalamus Mouse The mammalian hypothalamus regulates essential and dynamic physiological functions, including growth, metabolism, sleep, as well as reproductive behaviors ( Krononberg et al., 2007 ; Caqueret et al., 2005 ; Michaud, 2001 ). The hypothalamus comprises of complex...

...Andrea Wolf; Soojin Ryu The hypothalamus is a key integrative center in the brain that consists of diverse cell types required for a variety of functions including homeostasis, reproduction, stress response, social and cognitive behavior. Despite our knowledge of several transcription factors...

... both TH + (M) and Avpl + (O) axons. Neither is detected in fgf3 mutant NH (N,P). ( Q-T ) fgf3 mutants display normal numbers of Avpl + neurons in the hypothalamus (Q,R), but lose Avpl + axonal NH innervation (T), the hypophyseal artery and the two bilateral hypophyseal capillaries (T...

... and Medicine (TIGEM) and Institute of Genetics and Biophysics ‘A. Buzzati-Traverso’, CNR, via Pietro Castellino 111, 80131 Naples, Italy Competing interests statement The authors declare no competing financial interests. 28 10 2011 © 2012. Gene networks Hypothalamus...

... study shows that a subset of anterior floor plate-like cells gives rise to Fgf3 + SOX3 + progenitor cells, demonstrates a dual origin of infundibular cells and reveals a crucial role for FGF signalling in governing extended infundibular growth. FGF Floor plate Hypothalamus Chick...

... of specific dopaminergic neuron groups in the hypothalamus and posterior tuberculum. Knockdown of sim1 causes a dopaminergic phenotype similar to arnt2 mutants, suggesting that Sim1 acts as a binding partner of Arnt2, similar to their role in hypothalamic neuroendocrine cell specification. sim1, arnt2 and otp...

...Kyoji Ohyama; Raman Das; Marysia Placzek In the developing chick hypothalamus, Shh and BMPs are expressed in a spatially overlapping, but temporally consecutive, manner. Here, we demonstrate how the temporal integration of Shh and BMP signalling leads to the late acquisition of Pax7 expression...

... not affect global forebrain regional patterning, but has several important consequences on specific regions and neuronal populations. First, we show expanded Nkx2.1a expression and higher levels of cell proliferation in the cavefish basal diencephalon and hypothalamus. Second, we uncover an Nkx2.1b-Lhx6...

...Ji Eun Lee; Shan-Fu Wu; Lisa M. Goering; Richard I. Dorsky Although the functional importance of the hypothalamus has been demonstrated throughout vertebrates, the mechanisms controlling neurogenesis in this forebrain structure are poorly understood. We report that canonical Wnt signaling acts...

...-justine.qc.ca ) 4 10 2005 ©2005. 2005 Hypothalamus Transcription factor Mammillary body Mouse Sim1 Sim2 The mammillary bodies (MBs), which lie at the caudal end of the hypothalamus, are composed of the lateral and medial mammillary nuclei. The MBs participate in two pathways...